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Viruses 2017, 9(10), 287;

Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference

Department of Medicine, Lady Davis Institute-Jewish General Hospital, McGill University, Montreal, QC, H3T 1E2, Canada
Department of Microbiology and Immunology, New York Medical College, Valhalla, NY 10595, USA
School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang, Hebei 050017, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 6 September 2017 / Revised: 28 September 2017 / Accepted: 1 October 2017 / Published: 3 October 2017
(This article belongs to the Special Issue Homage to Mark Wainberg)
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Flaviviruses including Zika, Dengue and Hepatitis C virus cause debilitating diseases in humans, and the former are emerging as global health concerns with no antiviral treatments. We investigated Sophora Flavecens, used in Chinese medicine, as a source for antiviral compounds. We isolated Sophoraflavenone G and found that it inhibited Hepatitis C replication, but not Sendai or Vesicular Stomatitis Virus. Pre- and post-infection treatments demonstrated anti-flaviviral activity against Dengue and Zika virus, via viral RNA polymerase inhibition. These data suggest that Sophoraflavenone G represents a promising candidate regarding anti-Flaviviridae research. View Full-Text
Keywords: flavivirus; Zika virus; Dengue virus; antiviral; therapy; RNA polymerase flavivirus; Zika virus; Dengue virus; antiviral; therapy; RNA polymerase

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Sze, A.; Olagnier, D.; Hadj, S.B.; Han, X.; Tian, X.H.; Xu, H.-T.; Yang, L.; Shi, Q.; Wang, P.; Wainberg, M.A.; Wu, J.H.; Lin, R. Sophoraflavenone G Restricts Dengue and Zika Virus Infection via RNA Polymerase Interference. Viruses 2017, 9, 287.

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