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Open AccessReview

Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle

by 1,2,3,4, 1,2,3,4 and 1,2,3,4,*
1
Inserm, U1016, Institut Cochin, 75014 Paris, France
2
CNRS, UMR8104, 75014 Paris, France
3
University Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France
4
Institut Cochin, Department Infection, Immunity, Inflammation, 75014 Paris, France
*
Author to whom correspondence should be addressed.
Viruses 2017, 9(10), 270; https://doi.org/10.3390/v9100270
Received: 22 July 2017 / Revised: 19 September 2017 / Accepted: 21 September 2017 / Published: 23 September 2017
(This article belongs to the Special Issue Viruses and Autophagy)
Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response. View Full-Text
Keywords: HIV-1; autophagy; LC3-associated phagocytosis; Env; Tat; Nef; Vpu; LC3 HIV-1; autophagy; LC3-associated phagocytosis; Env; Tat; Nef; Vpu; LC3
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MDPI and ACS Style

Leymarie, O.; Lepont, L.; Berlioz-Torrent, C. Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle. Viruses 2017, 9, 270. https://doi.org/10.3390/v9100270

AMA Style

Leymarie O, Lepont L, Berlioz-Torrent C. Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle. Viruses. 2017; 9(10):270. https://doi.org/10.3390/v9100270

Chicago/Turabian Style

Leymarie, Olivier; Lepont, Leslie; Berlioz-Torrent, Clarisse. 2017. "Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle" Viruses 9, no. 10: 270. https://doi.org/10.3390/v9100270

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