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Astrovirus Pathogenesis

Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA
Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Author to whom correspondence should be addressed.
These authors have contributed equally to this paper.
Academic Editor: Eric O. Freed
Viruses 2017, 9(1), 22;
Received: 9 December 2016 / Revised: 17 January 2017 / Accepted: 17 January 2017 / Published: 22 January 2017
(This article belongs to the Special Issue Astroviruses)
PDF [991 KB, uploaded 22 January 2017]


Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems. View Full-Text
Keywords: astrovirus; pathogenesis; animal models; cell culture astrovirus; pathogenesis; animal models; cell culture

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Johnson, C.; Hargest, V.; Cortez, V.; Meliopoulos, V.A.; Schultz-Cherry, S. Astrovirus Pathogenesis. Viruses 2017, 9, 22.

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