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Viruses 2017, 9(1), 24;

Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay

Department of Biosciences, University of Helsinki, Helsinki FIN-00014, Finland
Department of Chemistry and Biochemistry, University of Bern, Bern CH-3012, Switzerland
Graduate School for Cellular and Biomedical Sciences, University of Bern, Bern CH-3012, Switzerland
Authors to whom correspondence should be addressed.
Academic Editors: Robert Hogg and Karen L. Beemon
Received: 18 November 2016 / Revised: 5 January 2017 / Accepted: 13 January 2017 / Published: 23 January 2017
(This article belongs to the Special Issue Viral Interactions with Host RNA Decay Pathways)
Full-Text   |   PDF [2459 KB, uploaded 23 January 2017]   |  


Nonsense-mediated mRNA decay (NMD), a cellular RNA turnover pathway targeting RNAs with features resulting in aberrant translation termination, has recently been found to restrict the replication of positive-stranded RNA ((+)RNA) viruses. As for every other antiviral immune system, there is also evidence of viruses interfering with and modulating NMD to their own advantage. This review will discuss our current understanding of why and how NMD targets viral RNAs, and elaborate counter-defense strategies viruses utilize to escape NMD. View Full-Text
Keywords: RNA quality control; gene expression; translation; RNA-protein interactions RNA quality control; gene expression; translation; RNA-protein interactions

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Balistreri, G.; Bognanni, C.; Mühlemann, O. Virus Escape and Manipulation of Cellular Nonsense-Mediated mRNA Decay. Viruses 2017, 9, 24.

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