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Promoter Motifs in NCLDVs: An Evolutionary Perspective

Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Minas Gerais, Brazil
Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE) UM63 CNRS 7278 IRD 198 INSERM U1095, Aix-Marseille Université., 27 Boulevard Jean Moulin, Faculté de Médecine, 13385 Marseille Cedex 05, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Eric Freed
Viruses 2017, 9(1), 16;
Received: 14 November 2016 / Revised: 30 December 2016 / Accepted: 5 January 2017 / Published: 20 January 2017
(This article belongs to the Special Issue Viruses of Protozoa)
For many years, gene expression in the three cellular domains has been studied in an attempt to discover sequences associated with the regulation of the transcription process. Some specific transcriptional features were described in viruses, although few studies have been devoted to understanding the evolutionary aspects related to the spread of promoter motifs through related viral families. The discovery of giant viruses and the proposition of the new viral order Megavirales that comprise a monophyletic group, named nucleo-cytoplasmic large DNA viruses (NCLDV), raised new questions in the field. Some putative promoter sequences have already been described for some NCLDV members, bringing new insights into the evolutionary history of these complex microorganisms. In this review, we summarize the main aspects of the transcription regulation process in the three domains of life, followed by a systematic description of what is currently known about promoter regions in several NCLDVs. We also discuss how the analysis of the promoter sequences could bring new ideas about the giant viruses’ evolution. Finally, considering a possible common ancestor for the NCLDV group, we discussed possible promoters’ evolutionary scenarios and propose the term “MEGA-box” to designate an ancestor promoter motif (‘TATATAAAATTGA’) that could be evolved gradually by nucleotides’ gain and loss and point mutations. View Full-Text
Keywords: megavirales; NCLDV; giant viruses; promoter; transcription; evolution; MEGA-box megavirales; NCLDV; giant viruses; promoter; transcription; evolution; MEGA-box
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Oliveira, G.P.; Andrade, A.C.S.P.; Rodrigues, R.A.L.; Arantes, T.S.; Boratto, P.V.M.; Silva, L.K.S.; Dornas, F.P.; Trindade, G.D.S.; Drumond, B.P.; La Scola, B.; Kroon, E.G.; Abrahão, J.S. Promoter Motifs in NCLDVs: An Evolutionary Perspective. Viruses 2017, 9, 16.

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