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Measles Virus Host Invasion and Pathogenesis

Department of Viroscience, Erasmus MC, 3015CN Rotterdam, The Netherlands
Centre for Cancer Research and Cell Biology, Queen’s University of Belfast, BT7 1NN Belfast, UK
Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
Author to whom correspondence should be addressed.
Academic Editor: Richard K. Plemper
Viruses 2016, 8(8), 210;
Received: 2 June 2016 / Revised: 20 July 2016 / Accepted: 21 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Recent Progress in Measles Virus Research)
Measles virus is a highly contagious negative strand RNA virus that is transmitted via the respiratory route and causes systemic disease in previously unexposed humans and non-human primates. Measles is characterised by fever and skin rash and usually associated with cough, coryza and conjunctivitis. A hallmark of measles is the transient immune suppression, leading to increased susceptibility to opportunistic infections. At the same time, the disease is paradoxically associated with induction of a robust virus-specific immune response, resulting in lifelong immunity to measles. Identification of CD150 and nectin-4 as cellular receptors for measles virus has led to new perspectives on tropism and pathogenesis. In vivo studies in non-human primates have shown that the virus initially infects CD150+ lymphocytes and dendritic cells, both in circulation and in lymphoid tissues, followed by virus transmission to nectin-4 expressing epithelial cells. The abilities of the virus to cause systemic infection, to transmit to numerous new hosts via droplets or aerosols and to suppress the host immune response for several months or even years after infection make measles a remarkable disease. This review briefly highlights current topics in studies of measles virus host invasion and pathogenesis. View Full-Text
Keywords: measles virus; immune suppression; pathogenesis; tropism; transmission measles virus; immune suppression; pathogenesis; tropism; transmission
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MDPI and ACS Style

Laksono, B.M.; De Vries, R.D.; McQuaid, S.; Duprex, W.P.; De Swart, R.L. Measles Virus Host Invasion and Pathogenesis. Viruses 2016, 8, 210.

AMA Style

Laksono BM, De Vries RD, McQuaid S, Duprex WP, De Swart RL. Measles Virus Host Invasion and Pathogenesis. Viruses. 2016; 8(8):210.

Chicago/Turabian Style

Laksono, Brigitta M., Rory D. De Vries, Stephen McQuaid, W. Paul Duprex, and Rik L. De Swart. 2016. "Measles Virus Host Invasion and Pathogenesis" Viruses 8, no. 8: 210.

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