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Viruses 2016, 8(6), 162;

Stress Response and Translation Control in Rotavirus Infection

Departamento de Génetica del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Avenida Universidad 2001, Colonia Chamilpa, Cuernavaca, Morelos 62210, Mexico
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Received: 7 April 2016 / Revised: 26 May 2016 / Accepted: 31 May 2016 / Published: 7 June 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
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The general stress and innate immune responses are closely linked and overlap at many levels. The outcomes of these responses serve to reprogram host expression patterns to prevent viral invasions. In turn, viruses counter attack these cell responses to ensure their replication. The mechanisms by which viruses attempt to control host cell responses are as varied as the number of different virus families. One of the most recurrent strategies used by viruses to control the antiviral response of the cell is to hijack the translation machinery of the host, such that viral proteins are preferentially synthesized, while the expression of the stress and antiviral responses of the cell are blocked at the translation level. Here, we will review how rotaviruses, an important agent of acute severe gastroenteritis in children, overcome the stress responses of the cell to establish a productive infectious cycle. View Full-Text
Keywords: rotavirus; antiviral response; stress response; unfolded protein response; protein synthesis; RNA granules; stress granules; processing bodies rotavirus; antiviral response; stress response; unfolded protein response; protein synthesis; RNA granules; stress granules; processing bodies

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López, S.; Oceguera, A.; Sandoval-Jaime, C. Stress Response and Translation Control in Rotavirus Infection. Viruses 2016, 8, 162.

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