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Viruses 2016, 8(6), 152;

Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada
Department of Medicine, McGill University, Montréal, QC H3A 0G4, Canada
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Received: 28 April 2016 / Revised: 16 May 2016 / Accepted: 19 May 2016 / Published: 24 May 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
Full-Text   |   PDF [3249 KB, uploaded 24 May 2016]   |  


The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs. View Full-Text
Keywords: PI3K; Akt; mTOR; virus; 4EBP1; autophagy PI3K; Akt; mTOR; virus; 4EBP1; autophagy

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Le Sage, V.; Cinti, A.; Amorim, R.; Mouland, A.J. Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway. Viruses 2016, 8, 152.

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