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Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway

1
HIV-1 RNA Trafficking Laboratory, Lady Davis Institute at the Jewish General Hospital, Montréal, QC H3T 1E2, Canada
2
Department of Medicine, McGill University, Montréal, QC H3A 0G4, Canada
*
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Viruses 2016, 8(6), 152; https://doi.org/10.3390/v8060152
Received: 28 April 2016 / Revised: 16 May 2016 / Accepted: 19 May 2016 / Published: 24 May 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
The mammalian target of rapamycin (mTOR) is a central regulator of gene expression, translation and various metabolic processes. Multiple extracellular (growth factors) and intracellular (energy status) molecular signals as well as a variety of stressors are integrated into the mTOR pathway. Viral infection is a significant stress that can activate, reduce or even suppress the mTOR signaling pathway. Consequently, viruses have evolved a plethora of different mechanisms to attack and co-opt the mTOR pathway in order to make the host cell a hospitable environment for replication. A more comprehensive knowledge of different viral interactions may provide fruitful targets for new antiviral drugs. View Full-Text
Keywords: PI3K; Akt; mTOR; virus; 4EBP1; autophagy PI3K; Akt; mTOR; virus; 4EBP1; autophagy
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Le Sage, V.; Cinti, A.; Amorim, R.; Mouland, A.J. Adapting the Stress Response: Viral Subversion of the mTOR Signaling Pathway. Viruses 2016, 8, 152.

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