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Viruses 2016, 8(2), 40;

Mother-to-Child Transmission of HTLV-1 Epidemiological Aspects, Mechanisms and Determinants of Mother-to-Child Transmission

Pasteur Institute, Virology Department, Epidemiology and Physiopathology of Oncogenic Viruses Unit, F-75015 Paris, France
UMR CNRS 3569, Paris 75015, France
Sorbonne Paris Cité, Cellule Pasteur, Université Paris Diderot, Institut Pasteur 75015, Paris
ANSES, Enteric Viruses Unit, Maisons-Alfort 94706, France
Author to whom correspondence should be addressed.
Academic Editor: Louis M. Mansky
Received: 6 November 2015 / Revised: 22 January 2016 / Accepted: 27 January 2016 / Published: 3 February 2016
(This article belongs to the Special Issue Recent Advances in HTLV Research 2015)
Full-Text   |   PDF [482 KB, uploaded 3 February 2016]   |  


Human T-cell Lymphotropic Virus type 1 (HTLV-1) is a human retrovirus that infects at least 5–10 million people worldwide, and is the etiological agent of a lymphoproliferative malignancy; Adult T-cell Leukemia/Lymphoma (ATLL); and a chronic neuromyelopathy, HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP), as well as other inflammatory diseases such as infective dermatitis and uveitis. Besides sexual intercourse and intravenous transmission, HTLV-1 can also be transmitted from infected mother to child during prolonged breastfeeding. Some characteristics that are linked to mother-to-child transmission (MTCT) of HTLV-1, such as the role of proviral load, antibody titer of the infected mother, and duration of breastfeeding, have been elucidated; however, most of the mechanisms underlying HTLV-1 transmission during breast feeding remain largely unknown, such as the sites of infection and cellular targets as well as the role of milk factors. The present review focuses on the latest findings and current opinions and perspectives on MTCT of HTLV-1. View Full-Text
Keywords: human; HTLV-1; intestinal barrier; retrovirus; breastfeeding human; HTLV-1; intestinal barrier; retrovirus; breastfeeding

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Percher, F.; Jeannin, P.; Martin-Latil, S.; Gessain, A.; Afonso, P.V.; Vidy-Roche, A.; Ceccaldi, P.-E. Mother-to-Child Transmission of HTLV-1 Epidemiological Aspects, Mechanisms and Determinants of Mother-to-Child Transmission. Viruses 2016, 8, 40.

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