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Clinical Implications of Antiviral Resistance in Influenza

1
Division of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, 9/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, China
2
Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, 1/F, Clinical Sciences Building, Prince of Wales Hospital, Shatin, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Curt Hagedorn
Viruses 2015, 7(9), 4929-4944; https://doi.org/10.3390/v7092850
Received: 26 May 2015 / Revised: 28 July 2015 / Accepted: 28 July 2015 / Published: 14 September 2015
(This article belongs to the Section Antivirals & Vaccines)
Influenza is a major cause of severe respiratory infections leading to excessive hospitalizations and deaths globally; annual epidemics, pandemics, and sporadic/endemic avian virus infections occur as a result of rapid, continuous evolution of influenza viruses. Emergence of antiviral resistance is of great clinical and public health concern. Currently available antiviral treatments include four neuraminidase inhibitors (oseltamivir, zanamivir, peramivir, laninamivir), M2-inibitors (amantadine, rimantadine), and a polymerase inhibitor (favipiravir). In this review, we focus on resistance issues related to the use of neuraminidase inhibitors (NAIs). Data on primary resistance, as well as secondary resistance related to NAI exposure will be presented. Their clinical implications, detection, and novel therapeutic options undergoing clinical trials are discussed. View Full-Text
Keywords: antiviral resistance; neuraminidase inhibitors; influenza viruses antiviral resistance; neuraminidase inhibitors; influenza viruses
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Li, T.C.M.; Chan, M.C.W.; Lee, N. Clinical Implications of Antiviral Resistance in Influenza. Viruses 2015, 7, 4929-4944.

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