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Viruses 2015, 7(7), 3552-3573;

Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis

Department of Molecular and Cell Biology, National Center of Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain
Laboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, 12071 Castellón, Spain
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editors: Luis Carrasco and José Luis Nieva
Received: 25 May 2015 / Revised: 24 June 2015 / Accepted: 29 June 2015 / Published: 3 July 2015
(This article belongs to the Special Issue Viroporins)
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Modification of host-cell ionic content is a significant issue for viruses, as several viral proteins displaying ion channel activity, named viroporins, have been identified. Viroporins interact with different cellular membranes and self-assemble forming ion conductive pores. In general, these channels display mild ion selectivity, and, eventually, membrane lipids play key structural and functional roles in the pore. Viroporins stimulate virus production through different mechanisms, and ion channel conductivity has been proved particularly relevant in several cases. Key stages of the viral cycle such as virus uncoating, transport and maturation are ion-influenced processes in many viral species. Besides boosting virus propagation, viroporins have also been associated with pathogenesis. Linking pathogenesis either to the ion conductivity or to other functions of viroporins has been elusive for a long time. This article summarizes novel pathways leading to disease stimulated by viroporin ion conduction, such as inflammasome driven immunopathology. View Full-Text
Keywords: viroporins; virus; ion channel; protein-lipid pore; replication; pathogenesis; inflammasome viroporins; virus; ion channel; protein-lipid pore; replication; pathogenesis; inflammasome

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Nieto-Torres, J.L.; Verdiá-Báguena, C.; Castaño-Rodriguez, C.; Aguilella, V.M.; Enjuanes, L. Relevance of Viroporin Ion Channel Activity on Viral Replication and Pathogenesis. Viruses 2015, 7, 3552-3573.

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