The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy
Abstract
:1. Human Papillomaviruses and Cancer
2. Differences between the High and Low Risk Viruses
Protein Name | Function | Reference |
---|---|---|
DLG1 | Polarity/tumour suppressor | [15,16,21,29,30,31,32,33,34] |
SCRIB | Polarity/tumour suppressor | [21,35,36] |
MAGI1/2/3 | Polarity/tumour suppressor | [24,32,37,38] |
PSD95 | Signaling complex scaffold | [39] |
TIP2/GIPC | TGF-β signaling | [40] |
NHERF1 | PI3K/AKT signaling | [41] |
MUPP1 | Signaling complex scaffold | [42] |
PATJ | Tight junction assembly | [43,44] |
PTPH1/PTPN3 | Protein tyrosine phosphatase | [45,46] |
PTPN13 | Non-receptor phosphatase | [47] |
PDZRN3/LNX3 | RING-containing ubiquitin ligase | [48] |
14-3-3 | Signaling complex adapter | [49,50] |
PAR3 | Polarity/tumour suppressor | [51] |
SNX27 | Endosomal trafficking/signaling | [26,27] |
ARHGEF12 | RhoGEF | [26] |
FRMPD2 | Tight junction formation | [26] |
LRRC7 | Normal synaptic spine function | [26] |
3. The E6 PBM and the Viral Life Cycle
4. The Role of the PBM in Transformation and Cancer
5. E6, Cell Adhesion and Polarity
6. The Multifunctionality of the E6 Oncoprotein
Acknowledgements
Conflicts of Interest
References
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Ganti, K.; Broniarczyk, J.; Manoubi, W.; Massimi, P.; Mittal, S.; Pim, D.; Szalmas, A.; Thatte, J.; Thomas, M.; Tomaić, V.; et al. The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses 2015, 7, 3530-3551. https://doi.org/10.3390/v7072785
Ganti K, Broniarczyk J, Manoubi W, Massimi P, Mittal S, Pim D, Szalmas A, Thatte J, Thomas M, Tomaić V, et al. The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses. 2015; 7(7):3530-3551. https://doi.org/10.3390/v7072785
Chicago/Turabian StyleGanti, Ketaki, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaić, and et al. 2015. "The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy" Viruses 7, no. 7: 3530-3551. https://doi.org/10.3390/v7072785