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Baculovirus-mediated Gene Delivery and RNAi Applications

1
Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio 70211 Finland
2
Gene Therapy Unit, Kuopio University Hospital, Kuopio 70211, Finland
3
Science Service Center, Kuopio University Hospital, Kuopio 70211, Finland
*
Author to whom correspondence should be addressed.
Academic Editor: Kenneth Lundstrom
Viruses 2015, 7(4), 2099-2125; https://doi.org/10.3390/v7042099
Received: 10 March 2015 / Revised: 2 April 2015 / Accepted: 16 April 2015 / Published: 22 April 2015
(This article belongs to the Special Issue Gene Therapy with Emphasis on RNA Interference)
Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications including protein production and gene transfer. Multiple in vitro and in vivo studies exist and support their use as gene delivery vehicles in vertebrate cells. Recently, baculoviruses have also demonstrated high potential in RNAi applications in which several advantages of the virus make it a promising tool for RNA gene transfer with high safety and wide tropism. View Full-Text
Keywords: baculovirus; gene transfer; viral vector; RNAi baculovirus; gene transfer; viral vector; RNAi
MDPI and ACS Style

Makkonen, K.-E.; Airenne, K.; Ylä-Herttulala, S. Baculovirus-mediated Gene Delivery and RNAi Applications. Viruses 2015, 7, 2099-2125.

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