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Viruses 2015, 7(4), 2099-2125;

Baculovirus-mediated Gene Delivery and RNAi Applications

Virtanen Institute, Department of Biotechnology and Molecular Medicine, University of Eastern Finland, Kuopio 70211 Finland
Gene Therapy Unit, Kuopio University Hospital, Kuopio 70211, Finland
Science Service Center, Kuopio University Hospital, Kuopio 70211, Finland
Author to whom correspondence should be addressed.
Academic Editor: Kenneth Lundstrom
Received: 10 March 2015 / Revised: 2 April 2015 / Accepted: 16 April 2015 / Published: 22 April 2015
(This article belongs to the Special Issue Gene Therapy with Emphasis on RNA Interference)
Full-Text   |   PDF [693 KB, uploaded 12 May 2015]


Baculoviruses are widely encountered in nature and a great deal of data is available about their safety and biology. Recently, these versatile, insect-specific viruses have demonstrated their usefulness in various biotechnological applications including protein production and gene transfer. Multiple in vitro and in vivo studies exist and support their use as gene delivery vehicles in vertebrate cells. Recently, baculoviruses have also demonstrated high potential in RNAi applications in which several advantages of the virus make it a promising tool for RNA gene transfer with high safety and wide tropism. View Full-Text
Keywords: baculovirus; gene transfer; viral vector; RNAi baculovirus; gene transfer; viral vector; RNAi
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Makkonen, K.-E.; Airenne, K.; Ylä-Herttulala, S. Baculovirus-mediated Gene Delivery and RNAi Applications. Viruses 2015, 7, 2099-2125.

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