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Viruses 2015, 7(11), 5746-5766;

Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications

Liver Unit, Internal Medicine, Laboratory of Malalties Hepàtiques, Vall d’Hebron Institut de Recerca-Hospital Universitari Vall d’Hebron (VHIR-HUVH), Universitat Autònoma de Barcelona, 08035 Barcelona, Spain
Centro de Biologia Molecular “Severo Ochoa” (CSIC-UAM), Cantoblanco, 28049 Madrid, Spain
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 08035 Barcelona, Spain
Universitat Autònoma de Barcelona, Bellaterra 08193, Spain
Roche Diagnostics SL, 08174 Sant Cugat del Vallès, Spain
Author to whom correspondence should be addressed.
Academic Editor: Thomas Baumert
Received: 22 September 2015 / Revised: 23 October 2015 / Accepted: 26 October 2015 / Published: 6 November 2015
(This article belongs to the Special Issue HCV Drug Resistance)
Full-Text   |   PDF [1847 KB, uploaded 6 November 2015]   |  


Selection of inhibitor-resistant viral mutants is universal for viruses that display quasi-species dynamics, and hepatitis C virus (HCV) is no exception. Here we review recent results on drug resistance in HCV, with emphasis on resistance to the newly-developed, directly-acting antiviral agents, as they are increasingly employed in the clinic. We put the experimental observations in the context of quasi-species dynamics, in particular what the genetic and phenotypic barriers to resistance mean in terms of exploration of sequence space while HCV replicates in the liver of infected patients or in cell culture. Strategies to diminish the probability of viral breakthrough during treatment are briefly outlined. View Full-Text
Keywords: viral quasi-species; hepatitis C virus; viral resistance; antiviral treatment viral quasi-species; hepatitis C virus; viral resistance; antiviral treatment

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Perales, C.; Quer, J.; Gregori, J.; Esteban, J.I.; Domingo, E. Resistance of Hepatitis C Virus to Inhibitors: Complexity and Clinical Implications. Viruses 2015, 7, 5746-5766.

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