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Volume 7
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10.3390/v7010027
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Communication

Is the New Variant RHDV Replacing Genogroup 1 in Portuguese Wild Rabbit Populations?

by
Ana M. Lopes
1,2,3,†,
Jorge Correia
4,†,
Joana Abrantes
1,
Pedro Melo
5,
Margarida Ramada
5,
Maria J. Magalhães
1,
Paulo C. Alves
1,2,6 and
Pedro J. Esteves
1,2,7,*
1
CIBIO, InBIO—Research Network in Biodiversity and Evolutionary Biology, Universidade do Porto, Campus de Vairão, Rua Padre Armando Quintas, 4485-661 Vairão, Portugal
2
Departamento de Biologia, Faculdade de Ciências da Universidade do Porto, Rua do Campo Alegre, s/n, 4169-007, Porto, Portugal
3
INSERM—Institut national de la santé et de la recherche médicale, U892, Université de Nantes, 44007 Nantes, France
4
CIISA—Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, 1300-477 Lisboa, Portugal
5
VETNATURA, 1600-176 Lisboa, Portugal
6
Wildlife Biology Program, University of Montana, 32 Campus Drive, Missoula, MT 59812, USA
7
CITS—Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, 4585-116 Gandra, Portugal
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2015, 7(1), 27-36; https://doi.org/10.3390/v7010027
Submission received: 6 November 2014 / Accepted: 19 December 2014 / Published: 30 December 2014
(This article belongs to the Section Animal Viruses)
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Abstract

The Lagovirus rabbit hemorrhagic disease virus (RHDV), a member of the family Caliciviridae, severely affects European rabbit (Oryctolagus cuniculus) populations by causing rabbit hemorrhagic disease (RHD). RHDV is subdivided in six genogroups but, more recently, a new RHDV variant with a unique genetic and antigenic profile emerged. We performed a study in rabbits found dead in the field during 2013 and 2014 in Portugal to determine the prevalence of this new variant versus the classical RHDV. Fifty-seven liver samples were screened for the presence of RHDV and positive samples were genotyped. All cases of RHDV infection were caused by the new variant. The only former genogroup circulating in Portugal, G1, was not detected. We hence conclude that the new RHDV variant is replacing G1 in Portugal, probably due to a selective advantage. This sudden and rapid replacement emphasizes the necessity of continued monitoring of wild rabbit populations.
Keywords: rabbit hemorrhagic disease virus (RHDV); rabbit hemorrhagic disease (RHD); new variant RHDV; genogroup 1; replacement; Portugal rabbit hemorrhagic disease virus (RHDV); rabbit hemorrhagic disease (RHD); new variant RHDV; genogroup 1; replacement; Portugal

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MDPI and ACS Style

Lopes, A.M.; Correia, J.; Abrantes, J.; Melo, P.; Ramada, M.; Magalhães, M.J.; Alves, P.C.; Esteves, P.J. Is the New Variant RHDV Replacing Genogroup 1 in Portuguese Wild Rabbit Populations? Viruses 2015, 7, 27-36. https://doi.org/10.3390/v7010027

AMA Style

Lopes AM, Correia J, Abrantes J, Melo P, Ramada M, Magalhães MJ, Alves PC, Esteves PJ. Is the New Variant RHDV Replacing Genogroup 1 in Portuguese Wild Rabbit Populations? Viruses. 2015; 7(1):27-36. https://doi.org/10.3390/v7010027

Chicago/Turabian Style

Lopes, Ana M., Jorge Correia, Joana Abrantes, Pedro Melo, Margarida Ramada, Maria J. Magalhães, Paulo C. Alves, and Pedro J. Esteves. 2015. "Is the New Variant RHDV Replacing Genogroup 1 in Portuguese Wild Rabbit Populations?" Viruses 7, no. 1: 27-36. https://doi.org/10.3390/v7010027

APA Style

Lopes, A. M., Correia, J., Abrantes, J., Melo, P., Ramada, M., Magalhães, M. J., Alves, P. C., & Esteves, P. J. (2015). Is the New Variant RHDV Replacing Genogroup 1 in Portuguese Wild Rabbit Populations? Viruses, 7(1), 27-36. https://doi.org/10.3390/v7010027

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