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Poxviruses in Bats … so What?
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Filoviruses in Bats: Current Knowledge and Future Directions

by Kevin J. Olival 1,*,† and David T. S. Hayman 2,3,4,†
1
EcoHealth Alliance, 460 W. 34th Street, New York, NY 10001, USA
2
Department of Biology, Colorado State University, Fort Collins, CO 80523, USA
3
Department of Biology, University of Florida, Gainesville, FL 32611, USA
4
Molecular Epidemiology and Public Health Laboratory, Hopkirk Research Institute, Massey University, Private Bag 11 222, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2014, 6(4), 1759-1788; https://doi.org/10.3390/v6041759
Received: 1 February 2014 / Revised: 1 April 2014 / Accepted: 2 April 2014 / Published: 17 April 2014
(This article belongs to the Special Issue Viruses and Bats)
Filoviruses, including Ebolavirus and Marburgvirus, pose significant threats to public health and species conservation by causing hemorrhagic fever outbreaks with high mortality rates. Since the first outbreak in 1967, their origins, natural history, and ecology remained elusive until recent studies linked them through molecular, serological, and virological studies to bats. We review the ecology, epidemiology, and natural history of these systems, drawing on examples from other bat-borne zoonoses, and highlight key areas for future research. We compare and contrast results from ecological and virological studies of bats and filoviruses with those of other systems. We also highlight how advanced methods, such as more recent serological assays, can be interlinked with flexible statistical methods and experimental studies to inform the field studies necessary to understand filovirus persistence in wildlife populations and cross-species transmission leading to outbreaks. We highlight the need for a more unified, global surveillance strategy for filoviruses in wildlife, and advocate for more integrated, multi-disciplinary approaches to understand dynamics in bat populations to ultimately mitigate or prevent potentially devastating disease outbreaks. View Full-Text
Keywords: bats; Chiroptera; disease ecology; emerging infectious diseases; Ebola; Filovirus; Lloviu; Marburg; Ravn; review bats; Chiroptera; disease ecology; emerging infectious diseases; Ebola; Filovirus; Lloviu; Marburg; Ravn; review
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Olival, K.J.; Hayman, D.T.S. Filoviruses in Bats: Current Knowledge and Future Directions. Viruses 2014, 6, 1759-1788.

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