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The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance
Open AccessReview

Current Perspectives on HIV-1 Antiretroviral Drug Resistance

Department of Pharmacology, School of Medicine, Yale University, New Haven, CT 06520, USA
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Viruses 2014, 6(10), 4095-4139; https://doi.org/10.3390/v6104095
Received: 28 July 2014 / Revised: 8 October 2014 / Accepted: 20 October 2014 / Published: 24 October 2014
(This article belongs to the Special Issue HIV Drug Resistance)
Current advancements in antiretroviral therapy (ART) have turned HIV-1 infection into a chronic and manageable disease. However, treatment is only effective until HIV-1 develops resistance against the administered drugs. The most recent antiretroviral drugs have become superior at delaying the evolution of acquired drug resistance. In this review, the viral fitness and its correlation to HIV-1 mutation rates and drug resistance are discussed while emphasizing the concept of lethal mutagenesis as an alternative therapy. The development of resistance to the different classes of approved drugs and the importance of monitoring antiretroviral drug resistance are also summarized briefly. View Full-Text
Keywords: HIV-1; antiviral therapy; drug resistance; evolution; lethal mutagenesis; resistance monitoring HIV-1; antiviral therapy; drug resistance; evolution; lethal mutagenesis; resistance monitoring
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MDPI and ACS Style

Iyidogan, P.; Anderson, K.S. Current Perspectives on HIV-1 Antiretroviral Drug Resistance. Viruses 2014, 6, 4095-4139.

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