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The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance

Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
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Author to whom correspondence should be addressed.
Current Address: Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Current Address: Bio-Rad Laboratories, 5500 East Second Street, Benicia, CA 94510, USA;
Viruses 2014, 6(10), 4080-4094; https://doi.org/10.3390/v6104080
Received: 13 August 2014 / Revised: 19 October 2014 / Accepted: 20 October 2014 / Published: 23 October 2014
(This article belongs to the Special Issue HIV Drug Resistance)
Mutations in HIV-1 reverse transcriptase (RT) that confer nucleoside analog RT inhibitor resistance have highlighted the functional importance of several active site residues (M184, Q151 and K65) in RT catalytic function. Of these, K65 residue is notable due to its pivotal position in the dNTP-binding pocket, its involvement in nucleoside analog resistance and polymerase fidelity. This review focuses on K65 residue and summarizes a substantial body of biochemical and structural studies of its role in RT function and the functional consequences of the K65R mutation. View Full-Text
Keywords: HIV-1 reverse transcriptase; NRTI analog resistance; K65R mutation; HIV-1 drug resistance; reverse transcriptase function; polymerase fidelity HIV-1 reverse transcriptase; NRTI analog resistance; K65R mutation; HIV-1 drug resistance; reverse transcriptase function; polymerase fidelity
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Garforth, S.J.; Lwatula, C.; Prasad, V.R. The Lysine 65 Residue in HIV-1 Reverse Transcriptase Function and in Nucleoside Analog Drug Resistance. Viruses 2014, 6, 4080-4094.

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