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Current Perspectives on HIV-1 Antiretroviral Drug Resistance
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Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding

by Moheshwarnath Issur 1 and Matthias Götte 1,2,3,*,†
1
Department of Microbiology and Immunology, McGill University, Montreal, QC H3A 2B4, Canada
2
Department of Biochemistry, McGill University, 3655 Sir William Osler Promenade, Montreal, QC H3G 1Y6, Canada
3
Department of Medicine, Division of Experimental Medicine, McGill University, 1110 Pine Avenue West, Montreal, QC H3A 1A3, Canada
*
Author to whom correspondence should be addressed.
Present Address: Department of Medical Microbiology and Immunology, University of Alberta, 6-020 Katz Group Centre, Edmonton, AB T6G 2E1, Canada.
Viruses 2014, 6(11), 4227-4241; https://doi.org/10.3390/v6114227
Received: 27 August 2014 / Revised: 22 October 2014 / Accepted: 22 October 2014 / Published: 6 November 2014
(This article belongs to the Special Issue HIV Drug Resistance)
Direct-acting antivirals (DAAs) have significantly improved the treatment of infection with the hepatitis C virus. A promising class of novel antiviral agents targets the HCV NS5A protein. The high potency and broad genotypic coverage are favorable properties. NS5A inhibitors are currently assessed in advanced clinical trials in combination with viral polymerase inhibitors and/or viral protease inhibitors. However, the clinical use of NS5A inhibitors is also associated with new challenges. HCV variants with decreased susceptibility to these drugs can emerge and compromise therapy. In this review, we discuss resistance patterns in NS5A with focus prevalence and implications for inhibitor binding. View Full-Text
Keywords: Daclatasvir; NS5A; HCV; resistance; resistance barrier; viral fitness; DAA Daclatasvir; NS5A; HCV; resistance; resistance barrier; viral fitness; DAA
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Issur, M.; Götte, M. Resistance Patterns Associated with HCV NS5A Inhibitors Provide Limited Insight into Drug Binding. Viruses 2014, 6, 4227-4241.

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