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Open AccessCommentary

Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data

1
Memorial Sloan Kettering Cancer Center, NY, NY and Howard Hughes Medical Institute, USA
2
The Fels Cancer Institute and Department of Microbiology Temple University School of Medicine, Philadelphia, PA, USA
3
The Wistar Institute Philadelphia, PA 19104, USA
*
Author to whom correspondence should be addressed.
Viruses 2013, 5(4), 1042-1054; https://doi.org/10.3390/v5041042
Received: 18 February 2013 / Revised: 11 March 2013 / Accepted: 18 March 2013 / Published: 2 April 2013
(This article belongs to the Special Issue Recent Progress in EBV Research)
The Epstein-Barr virus (EBV) double-stranded DNA genome is subject to extensive epigenetic regulation. Large consortiums and individual labs have generated a vast number of genome-wide data sets on human lymphoblastoid and other cell lines latently infected with EBV. Analysis of these data sets reveals important new information on the properties of the host and viral chromosome structure organization and epigenetic modifications. We discuss the mapping of these data sets and the subsequent insights into the chromatin structure and transcription factor binding patterns on latent EBV genomes. Colocalization of multiple histone modifications and transcription factors at regulatory loci are considered in the context of the biology and regulation of EBV. View Full-Text
Keywords: Epstein-Barr virus; gammaherpesvirus; chromatin; histone modification; CTCF; OriP Epstein-Barr virus; gammaherpesvirus; chromatin; histone modification; CTCF; OriP
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MDPI and ACS Style

Arvey, A.; Tempera, I.; Lieberman, P.M. Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data. Viruses 2013, 5, 1042-1054.

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