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Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA
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Viruses 2013, 5(1), 226-240; https://doi.org/10.3390/v5010226
Received: 5 December 2012 / Revised: 23 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013
(This article belongs to the Special Issue Recent Progress in EBV Research)
Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV. View Full-Text
Keywords: Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer
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Smith, D.W.; Sugden, B. Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus. Viruses 2013, 5, 226-240.

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