Next Article in Journal
Large Human Outbreak of West Nile Virus Infection in North-Eastern Italy in 2012
Next Article in Special Issue
The p36 Isoform of Murine Cytomegalovirus m152 Protein Suffices for Mediating Innate and Adaptive Immune Evasion
Previous Article in Journal
Large Scale Genome Analysis Shows that the Epitopes for Broadly Cross-Reactive Antibodies Are Predominant in the Pandemic 2009 Influenza Virus A H1N1 Strain

Human Cytomegalovirus Manipulation of Latently Infected Cells

Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, UK
Institute of Immunity and Transplantation, Division of Infection and Immunity, University College London, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK
Author to whom correspondence should be addressed.
Viruses 2013, 5(11), 2803-2824;
Received: 17 October 2013 / Revised: 11 November 2013 / Accepted: 13 November 2013 / Published: 21 November 2013
(This article belongs to the Special Issue Recent CMV Research)
Primary infection with human cytomegalovirus (HCMV) results in the establishment of a lifelong infection of the host which is aided by the ability of HCMV to undergo a latent infection. One site of HCMV latency in vivo is in haematopoietic progenitor cells, resident in the bone marrow, with genome carriage and reactivation being restricted to the cells of the myeloid lineage. Until recently, HCMV latency has been considered to be relatively quiescent with the virus being maintained essentially as a “silent partner” until conditions are met that trigger reactivation. However, advances in techniques to study global changes in gene expression have begun to show that HCMV latency is a highly active process which involves expression of specific latency-associated viral gene products which orchestrate major changes in the latently infected cell. These changes are argued to help maintain latent infection and to modulate the cellular environment to the benefit of latent virus. In this review, we will discuss these new findings and how they impact not only on our understanding of the biology of HCMV latency but also how they could provide tantalising glimpses into mechanisms that could become targets for the clearance of latent HCMV. View Full-Text
Keywords: cytomegalovirus; latency; immune evasion; apoptosis; gene expression; cellular signalling cytomegalovirus; latency; immune evasion; apoptosis; gene expression; cellular signalling
Show Figures

Figure 1

MDPI and ACS Style

Sinclair, J.H.; Reeves, M.B. Human Cytomegalovirus Manipulation of Latently Infected Cells. Viruses 2013, 5, 2803-2824.

AMA Style

Sinclair JH, Reeves MB. Human Cytomegalovirus Manipulation of Latently Infected Cells. Viruses. 2013; 5(11):2803-2824.

Chicago/Turabian Style

Sinclair, John H., and Matthew B. Reeves. 2013. "Human Cytomegalovirus Manipulation of Latently Infected Cells" Viruses 5, no. 11: 2803-2824.

Find Other Styles

Article Access Map by Country/Region

Only visits after 24 November 2015 are recorded.
Back to TopTop