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Viruses 2013, 5(10), 2410-2423;

Viruses Challenge Selectivity Barrier of Nuclear Pores

The Wohl Virion Centre and MRC Centre for Medical & Molecular Virology, Division of Infection and Immunity, University College London, Cruciform Building, 90 Gower Street, London WC1E6BT, UK
Authors to whom correspondence should be addressed.
Received: 20 August 2013 / Revised: 24 September 2013 / Accepted: 25 September 2013 / Published: 30 September 2013
(This article belongs to the Special Issue Viral Nuclear Import)
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Exchange between the nucleus and the cytoplasm occurs through nuclear pore complexes (NPCs) embedded in the double membrane of the nuclear envelope. NPC permeability barrier restricts the entry of inert molecules larger than 5 nm in diameter but allows facilitated entry of selected cargos, whose size can reach up to 39 nm. The translocation of large molecules is facilitated by nuclear transport receptors (NTRs) that have affinity to proteins of NPC permeability barrier. Viruses that enter the nucleus replicate evolved strategies to overcome this barrier. In this review, we will discuss the functional principles of NPC barrier and nuclear transport machinery, as well as the various strategies viruses use to cross the selective barrier of NPCs. View Full-Text
Keywords: NPC; importin; exportin; nucleoporin; FG hydrogel; viral capsid NPC; importin; exportin; nucleoporin; FG hydrogel; viral capsid

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Labokha, A.A.; Fassati, A. Viruses Challenge Selectivity Barrier of Nuclear Pores. Viruses 2013, 5, 2410-2423.

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