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Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

Paramyxovirus Fusion and Entry: Multiple Paths to a Common End

Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
Author to whom correspondence should be addressed.
Viruses 2012, 4(4), 613-636;
Received: 8 March 2012 / Revised: 10 March 2012 / Accepted: 12 April 2012 / Published: 19 April 2012
(This article belongs to the Special Issue Virus-Induced Membrane Fusion)
The paramyxovirus family contains many common human pathogenic viruses, including measles, mumps, the parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and the zoonotic henipaviruses, Hendra and Nipah. While the expression of a type 1 fusion protein and a type 2 attachment protein is common to all paramyxoviruses, there is considerable variation in viral attachment, the activation and triggering of the fusion protein, and the process of viral entry. In this review, we discuss recent advances in the understanding of paramyxovirus F protein-mediated membrane fusion, an essential process in viral infectivity. We also review the role of the other surface glycoproteins in receptor binding and viral entry, and the implications for viral infection. Throughout, we concentrate on the commonalities and differences in fusion triggering and viral entry among the members of the family. Finally, we highlight key unanswered questions and how further studies can identify novel targets for the development of therapeutic treatments against these human pathogens. View Full-Text
Keywords: paramyxovirus; membrane fusion; viral entry paramyxovirus; membrane fusion; viral entry
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MDPI and ACS Style

Chang, A.; Dutch, R.E. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End. Viruses 2012, 4, 613-636.

AMA Style

Chang A, Dutch RE. Paramyxovirus Fusion and Entry: Multiple Paths to a Common End. Viruses. 2012; 4(4):613-636.

Chicago/Turabian Style

Chang, Andres, and Rebecca E. Dutch. 2012. "Paramyxovirus Fusion and Entry: Multiple Paths to a Common End" Viruses 4, no. 4: 613-636.

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