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Involvement of Autophagy in Coronavirus Replication

Avian Viral Diseases, The Pirbright Institute, Compton Laboratory, High Street, Compton, Newbury, Berkshire, RG20 7NN, UK
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Viruses 2012, 4(12), 3440-3451; https://doi.org/10.3390/v4123440
Received: 27 September 2012 / Revised: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
(This article belongs to the Special Issue Perspectives and Challenges in Coronavirus Research)
Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3) in coronavirus replication. View Full-Text
Keywords: coronavirus; IBV; autophagy; double membrane vesicles; replication-transcription complexes coronavirus; IBV; autophagy; double membrane vesicles; replication-transcription complexes
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Maier, H.J.; Britton, P. Involvement of Autophagy in Coronavirus Replication. Viruses 2012, 4, 3440-3451.

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