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Correlates of Immunity to Filovirus Infection

United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, MD 21702, USA
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Viruses 2011, 3(7), 982-1000; https://doi.org/10.3390/v3070982
Received: 14 April 2011 / Revised: 14 June 2011 / Accepted: 16 June 2011 / Published: 27 June 2011
(This article belongs to the Special Issue Pathogenesis of Emerging and Re-Emerging RNA Viruses)
Filoviruses can cause severe, often fatal hemorrhagic fever in humans. Recent advances in vaccine and therapeutic drug development have provided encouraging data concerning treatment of these infections. However, relatively little is known about immune responses in fatal versus non-fatal filovirus infection. This review summarizes the published literature on correlates of immunity to filovirus infection, and highlights deficiencies in our knowledge on this topic. It is likely that there are several types of successful immune responses, depending on the type of filovirus, and the presence and timing of vaccination or drug treatment.
Keywords: filovirus; ebola; marburg; immunity
filovirus; ebola; marburg; immunity
MDPI and ACS Style

Bradfute, S.B.; Bavari, S. Correlates of Immunity to Filovirus Infection. Viruses 2011, 3, 982-1000.

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