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T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome

Center for Infectious Disease and Vaccine Research, Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
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Viruses 2011, 3(7), 1059-1073; https://doi.org/10.3390/v3071059
Received: 31 March 2011 / Revised: 30 June 2011 / Accepted: 1 July 2011 / Published: 6 July 2011
(This article belongs to the Special Issue Pathogenesis of Emerging and Re-Emerging RNA Viruses)
We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical observations and in vitro experiments. In HCPS, hantavirus-specific T cell responses positively correlated with disease severity. In HFRS, in one report, contrary to HCPS, T cell responses negatively correlated with disease severity, but in another report the number of regulatory T cells, which are thought to suppress T cell responses, negatively correlated with disease severity. In rat experiments, in which hantavirus causes persistent infection, depletion of regulatory T cells helped infected rats clear virus without inducing immunopathology. These seemingly contradictory findings may suggest delicate balance in T cell responses between protection and immunopathogenesis. Both too strong and too weak T cell responses may lead to severe disease. It is important to clarify the role of T cells in these diseases for better treatment (whether to suppress T cell functions) and protection (vaccine design) which may need to take into account viral factors and the influence of HLA on T cell responses.
Keywords: hantavirus; hantavirus cardiopulmonary syndrome; hemorrhagic fever with renal syndrome; immunopathogenesis; CD8+ T cell; regulatory T cell; endothelial cell hantavirus; hantavirus cardiopulmonary syndrome; hemorrhagic fever with renal syndrome; immunopathogenesis; CD8+ T cell; regulatory T cell; endothelial cell
MDPI and ACS Style

Terajima, M.; Ennis, F.A. T Cells and Pathogenesis of Hantavirus Cardiopulmonary Syndrome and Hemorrhagic Fever with Renal Syndrome. Viruses 2011, 3, 1059-1073.

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