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Antiviral Strategies for Pandemic and Seasonal Influenza

NexBio, Inc./10665 Sorrento Valley Rd, San Diego, CA 92121, USA
Author to whom correspondence should be addressed.
Viruses 2010, 2(8), 1766-1781;
Received: 11 June 2010 / Revised: 6 August 2010 / Accepted: 11 August 2010 / Published: 20 August 2010
(This article belongs to the Special Issue Antivirals Against Influenza)
PDF [259 KB, uploaded 12 May 2015]


While vaccines are the primary public health response to seasonal and pandemic flu, short of a universal vaccine there are inherent limitations to this approach. Antiviral drugs provide valuable alternative options for treatment and prophylaxis of influenza. Here, we will review drugs and drug candidates against influenza with an emphasis on the recent progress of a host-targeting entry-blocker drug candidate, DAS181, a sialidase fusion protein.
Keywords: influenza virus; neuraminidase inhibitors; sialic acid; RNA polymerase influenza virus; neuraminidase inhibitors; sialic acid; RNA polymerase
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Hedlund, M.; Larson, J.L.; Fang, F. Antiviral Strategies for Pandemic and Seasonal Influenza. Viruses 2010, 2, 1766-1781.

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