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Viruses 2010, 2(4), 1011-1049;

Glycosphingolipids as Receptors for Non-Enveloped Viruses

Department of Microbiology and Immunology, University of Michigan Medical School, 5622 Medical Sciences Bldg. II, 1150 West Medical Center Dr., Ann Arbor, MI 48109, USA
These authors contributed equally to the work.
Author to whom correspondence should be addressed.
Received: 2 March 2010 / Revised: 9 April 2010 / Accepted: 13 April 2010 / Published: 15 April 2010
(This article belongs to the Special Issue Role of Lipids in Virus Replication)
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Glycosphingolipids are ubiquitous molecules composed of a lipid and a carbohydrate moiety. Their main functions are as antigen/toxin receptors, in cell adhesion/recognition processes, or initiation/modulation of signal transduction pathways. Microbes take advantage of the different carbohydrate structures displayed on a specific cell surface for attachment during infection. For some viruses, such as the polyomaviruses, binding to gangliosides determines the internalization pathway into cells. For others, the interaction between microbe and carbohydrate can be a critical determinant for host susceptibility. In this review, we summarize the role of glycosphingolipids as receptors for members of the non-enveloped calici-, rota-, polyoma- and parvovirus families. View Full-Text
Keywords: non-enveloped virus; glycosphingolipid; receptor; calicivirus; rotavirus; polyomavirus; parvovirus non-enveloped virus; glycosphingolipid; receptor; calicivirus; rotavirus; polyomavirus; parvovirus

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Taube, S.; Jiang, M.; Wobus, C.E. Glycosphingolipids as Receptors for Non-Enveloped Viruses. Viruses 2010, 2, 1011-1049.

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