Soluble Neuropilin-1 as a Marker for Distinguishing Bacterial and Viral Sepsis in Critically Ill Patients—A Prospective, Multicenter, Observational Study
, Georg Franz Lehner 1, Timo Mayerhöfer 1, Frank Hartig 1, Birgit Zassler 1, Johannes Bösch 2, Dietmar Fries 2, Romuald Bellmann 1 and Michael Joannidis 1,*Round 1
Reviewer 1 Report
Comments and Suggestions for Authorsplease see the attached file.
Comments for author File: 
Comments.pdf
Some grammar mistakes should be revised.
Author Response
Please see the attachment.
Author Response File: 
Author Response.docx
Reviewer 2 Report
Comments and Suggestions for AuthorsThe authors investigated whether soluble neuropilin-1 (sNRP-1) is suitable for differentiating between bacterial and viral causes of septic patients. After a brief introduction to the very relevant topic, the material and methods are presented; the patients were part of the SEPSIS-3 study. Please indicate the ethics vote. PCT, IL-6, CRP and sNRP-1 were determined in arterial plasma after storage at -80°C. A total of 51 patients could be included. IL-6 and CRP were only higher in the first 4 days of a bacterial infection than in viral infections, while PCT and sNRP-1 differed throughout the entire week of observation. From day 4 onwards, this was no longer significant for sNRP-1. The conclusion that this is a promising marker is probably a little too optimistic, but this may change with further findings on sNRP-1 regulation.
Author Response
Please see the attachment.
Author Response File: Author Response.docx
