Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021
Abstract
:1. Introduction
2. Material and Methods
2.1. Study Population
2.2. Viral Screening
2.3. HAdV, HBoV, NoV, EV, and PeV-A Typing
2.4. Phylogenetic Analysis
3. Results
3.1. Clinical Findings
3.2. Viral Diagnosis
3.3. Genotypic Data
3.4. Phylogenetic Data
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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ID | Gender | Age | Onset Date | Collection Date | City | Signs and Symptoms | HBoV, Type | RVA | HAdV, Type | EV, Type | SARS-CoV-2 | Flu A/B | RSV | HAstV | NoV, Group | NoV Strain | PeV-A, Type | Sample |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N01 | Male | 1 year | August 8 | August 30 | Barueri | Diarrhea | +, NT | - | - | - | - | - | + | - | - | - | Swab | |
- | - | - | - | - | - | + | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N02 | Male | 1 year | August 28 | September 3 | Barueri | Diarrhea, vomiting, coryza, cough, fever | +, NT | - | - | - | - | - | - | - | - | - | Swab | |
- | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N03 | Female | 1 year | August 31 | September 3 | Carapicuiba | Diarrhea | +, NT | - | - | - | - | - | + | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | +, GII | NT | - | Feces | |||||||
N04 | Male | 2 years | September 5 | September 5 | Barueri | Diarrhea, vomiting | +, HBoV-1 | - | - | +, CVA6 | - | - | - | - | - | - | Swab | |
+, HBoV-1 | - | - | +, CVA6 | - | - | - | - | +, GII | GII.4 Sydney[P31] | - | Feces | |||||||
N05 | Female | 1 year | September 5 | September 6 | Osasco | Diarrhea, cough, fever | +, HBoV-1 | - | - | - | - | - | - | - | - | - | Swab | |
+, HBoV-1 | - | - | - | - | - | - | - | +, GII | GII.2[P16] | - | Feces | |||||||
N06 | Female | 6 months | September 6 | September 8 | Osasco | Diarrhea, cough, vomiting | - | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | +, NT | Feces |
N07 | Female | 1 year | September 9 | September 10 | Barueri | Diarrhea | +, HBoV-1 | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces |
N08 | Male | 2 years | September 12 | September 13 | Barueri | Diarrhea, vomiting, coryza, fever, productive cough, abdominal pain | +, HBoV-1 | - | - | - | - | - | - | - | +, GII | NT | - | Feces |
N09 | Male | 3 years | September 20 | September 21 | Barueri | Diarrhea, vomiting | - | - | - | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | +, GII | GII.2[P16] | - | Feces | |||||||
N10 | Male | 20 days | September 18 | September 21 | Barueri | Vomiting, fever | +, HBoV-1 | - | - | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | - | - | Feces | ||||||||
N11 | Female | 1 year | September 12 | September 13 | Carapicuiba | Diarrhea, vomiting, coryza, cough, fever | - | - | - | - | - | - | - | - | - | - | Swab | |
+, HBoV-1 | - | +, C6 | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N12 | Male | 2 years | September 20 | September 22 | Barueri | Diarrhea, vomiting, coryza, sore throat, abdominal pain | +, HBoV-1 | - | - | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N13 | Male | 11 days | September 20 | September 21 | Barueri | Fever | +, NT | - | - | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | - | - | Feces | ||||||||
N14 | Female | 6 months | September 26 | September 28 | Carapicuiba | Diarrhea, cough | - | - | - | - | - | - | - | - | - | - | Swab | |
- | - | - | - | - | - | - | - | - | - | Feces | ||||||||
N15 | Male | 1 year | October 2 | October 8 | Sao Paulo | Diarrhea, vomiting, coryza, fever, sneeze, productive cough, abdominal pain | +, HBoV-1 | - | +, C6 | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | +, GII | GII.2[P16] | - | Feces | |||||||
N16 | Female | 1 year | October 7 | October 9 | Barueri | Diarrhea, Fever | +, NT | - | - | - | - | - | - | - | - | - | Swab | |
+, NT | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N17 | Female | 5 months | October 11 | October 11 | Osasco | Diarrhea, vomiting | - | - | - | +, CVA6 | - | - | - | - | - | - | Swab | |
- | - | - | +, CVA6 | - | - | - | - | +, GII | GII.4 Sydney[P16] | +, PeV-A1 | Feces | |||||||
N18 | Male | 1 year | October 14 | October 17 | Carapicuiba | Diarrhea, vomiting, coryza, sneeze, productive cough | +, NT | - | - | - | - | - | - | - | - | - | Swab | |
- | - | - | - | - | - | - | - | +, GII | GII.4 Sydney[P16] | - | Feces | |||||||
N19 | Male | 1 year | November 30 | December 4 | Itapevi | Diarrhea, coryza, productive cough, fever | - | - | - | - | - | - | - | - | - | - | Swab | |
- | - | - | - | - | - | - | - | - | - | Feces | ||||||||
N20 | Male | 2 years | December 2 | December 6 | Carapicuiba | Diarrhea, vomiting, coryza, cough | - | - | - | - | - | Flu A | - | - | - | - | Swab | |
- | - | - | - | - | - | - | - | - | - | Feces |
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Luchs, A.; Adiwardana, N.S.; Rocha, L.C.d.; Viana, E.; Guadagnucci, S.; Parise, A.; Silva, V.C.M.; Azevedo, L.S.d.; Guiducci, R.; França, Y.; et al. Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021. Viruses 2025, 17, 497. https://doi.org/10.3390/v17040497
Luchs A, Adiwardana NS, Rocha LCd, Viana E, Guadagnucci S, Parise A, Silva VCM, Azevedo LSd, Guiducci R, França Y, et al. Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021. Viruses. 2025; 17(4):497. https://doi.org/10.3390/v17040497
Chicago/Turabian StyleLuchs, Adriana, Natanael Sutikno Adiwardana, Leonardo Cecilio da Rocha, Ellen Viana, Simone Guadagnucci, Adriana Parise, Vanessa Cristina Martins Silva, Lais Sampaio de Azevedo, Raquel Guiducci, Yasmin França, and et al. 2025. "Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021" Viruses 17, no. 4: 497. https://doi.org/10.3390/v17040497
APA StyleLuchs, A., Adiwardana, N. S., Rocha, L. C. d., Viana, E., Guadagnucci, S., Parise, A., Silva, V. C. M., Azevedo, L. S. d., Guiducci, R., França, Y., Frank, N. L. P., Silva, A. L. N. d., Oliveira, A. L. V. d., Azevedo, A. H. S., Carreteiro, B. S., & Nogueira, M. L. (2025). Concurrent Circulation of Viral Agents in Pediatric Patients Presenting with Respiratory Illness and Diarrheal Symptoms in Metropolitan Region of São Paulo, Brazil, 2021. Viruses, 17(4), 497. https://doi.org/10.3390/v17040497