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10.3390/v16071174
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Article

Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023

by
Ruihong Gao
1,2,3,*,†,
Wentong Li
1,2,3,†,
Jihong Xu
3,†,
Jiane Guo
3,
Rui Wang
3,
Shuting Zhang
3,
Xiaonan Zheng
3 and
Jitao Wang
2,3,*
1
Academy of Medical Sciences, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China
2
School of Public Health, Shanxi Medical University, 56 Xinjian South Road, Taiyuan 030001, Shanxi, China
3
Taiyuan Center for Disease Control and Prevention, No. 22, Huazhang West Street, Xiaodian District, Taiyuan 030012, Shanxi, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Viruses 2024, 16(7), 1174; https://doi.org/10.3390/v16071174
Submission received: 22 June 2024 / Revised: 18 July 2024 / Accepted: 19 July 2024 / Published: 22 July 2024
(This article belongs to the Section Human Virology and Viral Diseases)
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Abstract

The HIV-1 pandemic, spanning four decades, presents a significant challenge to global public health. This study aimed to understand the molecular transmission characteristics of newly reported HIV infections in Taiyuan, Shanxi Province, China, to analyze the characteristics of subtypes and the risk factors of the transmission network, providing a scientific basis for precise prevention and intervention measures. A total of 720 samples were collected from newly diagnosed HIV-1 patients residing in Taiyuan between 2021 and 2023. Sequencing of partial genes of the HIV-1 pol gene resulted in multiple sequence acquisitions and was conducted to analyze their subtypes and molecular transmission networks. Out of the samples, 584 pol sequences were obtained, revealing 17 HIV-1 subtypes, with CRF07_BC (48.29%), CRF01_AE (31.34%), and CRF79_0107 (7.19%) being the dominant subtypes. Using a genetic distance threshold of 1.5%, 49 molecular transmission clusters were generated from the 313 pol gene sequences. Univariate analysis showed significant differences in the HIV transmission molecular network in terms of HIV subtype and household registration (p < 0.05). Multivariate logistic regression analysis showed that CRF79_0107 subtype and its migrants were associated with higher proportions of sequences in the HIV transmission network. These findings provide a scientific foundation for the development of localized HIV-specific intervention strategies.
Keywords: HIV-1; subtype; cluster; transmission network; molecular epidemiology HIV-1; subtype; cluster; transmission network; molecular epidemiology

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MDPI and ACS Style

Gao, R.; Li, W.; Xu, J.; Guo, J.; Wang, R.; Zhang, S.; Zheng, X.; Wang, J. Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023. Viruses 2024, 16, 1174. https://doi.org/10.3390/v16071174

AMA Style

Gao R, Li W, Xu J, Guo J, Wang R, Zhang S, Zheng X, Wang J. Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023. Viruses. 2024; 16(7):1174. https://doi.org/10.3390/v16071174

Chicago/Turabian Style

Gao, Ruihong, Wentong Li, Jihong Xu, Jiane Guo, Rui Wang, Shuting Zhang, Xiaonan Zheng, and Jitao Wang. 2024. "Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023" Viruses 16, no. 7: 1174. https://doi.org/10.3390/v16071174

APA Style

Gao, R., Li, W., Xu, J., Guo, J., Wang, R., Zhang, S., Zheng, X., & Wang, J. (2024). Characteristics of Subtype and Molecular Transmission Networks among Newly Diagnosed HIV-1 Infections in Patients Residing in Taiyuan City, Shanxi Province, China, from 2021 to 2023. Viruses, 16(7), 1174. https://doi.org/10.3390/v16071174

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