Error in Table
In the original publication [1], incorrect numerical data were entered into the last three numbers in the AUC column of Table 5 and this mistake was not recognized by our review team. This error was identified by Sally Coggins who brought it to our attention. Corrected Table 5 appears below.
Table 5.
Pharmacokinetic parameters for GS-441524 after a single IV dose of RDV (7 mg/kg) in 3 cats.
Table 5.
Pharmacokinetic parameters for GS-441524 after a single IV dose of RDV (7 mg/kg) in 3 cats.
| Cat ID | Cmax (ng/mL; μM) | Tmax (h) | T1/2 (h) | AUC (h*ng/mL) |
|---|---|---|---|---|
| 20-045 | 1730 (5.94) | 0.5 | 5.3 | 14,271 |
| 21-001 | 1960 (6.73) | 1 | 5.7 | 15,291 |
| 21-004 | 2320 (7.97) | 1 | 4.5 | 9924 |
| Mean | 2003 (6.88) | 0.83 | 5.2 | 13,162 |
| SD | 297 (1.0) | 0.29 | 0.6 | 2850 |
Text Correction
With regard to the correction of Table 5, a correction has been made to Section 3.4, Paragraph 3.
“Finally, in the IV RDV cohort, GS-441524 exhibited an average plasma Cmax of 2003 ng/mL (6.9 μM) at a corresponding Tmax of 0.83 h and an average AUC0-24 value of 13,162 h*ng/mL (45 μM*h; average C24 = 64 ± 32 ng/mL, 0.22 ± 0.11 μM) (Table 5).”
The authors state that the scientific conclusions are unaffected. This correction was approved by the Academic Editor. The original publication has also been updated.
Reference
- Cook, S.; Wittenburg, L.; Yan, V.C.; Theil, J.H.; Castillo, D.; Reagan, K.; Williams, S.; Pham, C.-D.; Li, C.; Muller, F.L.; et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14, 2429. [Google Scholar] [CrossRef] [PubMed]
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