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Article

Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program

1
Departamento de Pesquisa & Desenvolvimento, Instituto Hermes Pardini, Belo Horizonte 31270-901, Brazil
2
Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil
3
Departamento de Genética, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-971, Brazil
*
Authors to whom correspondence should be addressed.
Academic Editors: Luis Martinez-Sobrido and Fernando Almazan Toral
Viruses 2022, 14(5), 847; https://doi.org/10.3390/v14050847
Received: 3 February 2022 / Revised: 16 March 2022 / Accepted: 17 March 2022 / Published: 20 April 2022
(This article belongs to the Collection SARS-CoV-2 and COVID-19)
Coronavirus disease 2019 (COVID-19) pandemic has caused immeasurable impacts on the health and socioeconomic system. The real-time identification and characterization of new Variants of Concern (VOCs) are critical to comprehend its emergence and spread worldwide. In this sense, we carried out a national epidemiological surveillance program in Brazil from April to October 2021. Genotyping by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and sequencing were performed to monitor the dynamics and dissemination of VOCs in samples from 15 federative units. Delta VOC was first detected on June 2021 and took sixteen weeks to replace Gamma. To assess the transmissibility potential of Gamma and Delta VOCs, we studied the dynamics of RT-qPCR cycle threshold (Ct) score in the dominance period of each variant. The data suggest that Delta VOC has a higher transmission rate than Gamma VOC. We also compared relevant symptom patterns in individuals infected with both VOCs. The Delta-infected subjects were less likely to have low oxygen saturation or fatigue, altered results on chest computed tomography, and a propensity for altered X-rays. Altogether, we described the replacement of Gamma by Delta, Delta enhanced transmissibility, and differences in symptom presentation. View Full-Text
Keywords: SARS-CoV-2; variants; epidemiologic surveillance; COVID-19; transmission; symptoms SARS-CoV-2; variants; epidemiologic surveillance; COVID-19; transmission; symptoms
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MDPI and ACS Style

Silva, J.P.; de Lima, A.B.; Alvim, L.B.; Malta, F.S.V.; Mendonça, C.P.T.B.; Fonseca, P.L.C.; Moreira, F.R.R.; Queiroz, D.C.; Ferreira, J.G.G.; Ferreira, A.C.S.; Souza, R.P.; Aguiar, R.S.; Zauli, D.A.G. Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program. Viruses 2022, 14, 847. https://doi.org/10.3390/v14050847

AMA Style

Silva JP, de Lima AB, Alvim LB, Malta FSV, Mendonça CPTB, Fonseca PLC, Moreira FRR, Queiroz DC, Ferreira JGG, Ferreira ACS, Souza RP, Aguiar RS, Zauli DAG. Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program. Viruses. 2022; 14(5):847. https://doi.org/10.3390/v14050847

Chicago/Turabian Style

Silva, Joice P., Aline B. de Lima, Luige B. Alvim, Frederico S.V. Malta, Cristiane P.T.B. Mendonça, Paula L.C. Fonseca, Filipe R.R. Moreira, Daniel C. Queiroz, Jorge G.G. Ferreira, Alessandro C.S. Ferreira, Renan P. Souza, Renato S. Aguiar, and Danielle A.G. Zauli. 2022. "Delta Variant of SARS-CoV-2 Replacement in Brazil: A National Epidemiologic Surveillance Program" Viruses 14, no. 5: 847. https://doi.org/10.3390/v14050847

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