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Updates on HTLV-1 Uveitis

Department of Ophthalmology & Visual Science, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
Department of Practical Management of Medical Information, St. Marianna University School of Medicine, Kanagawa 216-8512, Japan
Department of Medical Computational Biology and Genome Sciences, Laboratory of Tumor Cell Biology, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639, Japan
Department of Rheumatology, Infectious Diseases and Laboratory Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki 889-1601, Japan
Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine, Kanagawa 216-8511, Japan
Department of Safety Research on Blood and Biological Products, National Institute of Infectious Diseases, Tokyo 208-0011, Japan
Institute of Innovation Advancement, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
Author to whom correspondence should be addressed.
Academic Editor: Takuya Fukushima
Viruses 2022, 14(4), 794;
Received: 26 February 2022 / Revised: 7 April 2022 / Accepted: 8 April 2022 / Published: 12 April 2022
(This article belongs to the Special Issue HTLV-1 and HTLV-1-Associated Diseases)
HTLV-1 uveitis (HU) is the third clinical entity to be designated as an HTLV-1-associated disease. Although HU is considered to be the second-most frequent HTLV-1-associated disease in Japan, information on HU is limited compared to that on adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). Recent studies have addressed several long-standing uncertainties about HU. HTLV-1-related diseases are known to be caused mainly through vertical transmission (mother-to-child transmission), but emerging HTLV-1 infection by horizontal transmission (such as sexual transmission) has become a major problem in metropolitan areas, such as Tokyo, Japan. Investigation in Tokyo showed that horizontal transmission of HTLV-1 was responsible for HU with severe and persistent ocular inflammation. The development of ATL and HAM is known to be related to a high provirus load and hence involves a long latency period. On the other hand, factors contributing to the development of HU are poorly understood. Recent investigations revealed that severe HU occurs against a background of Graves’ disease despite a low provirus load and short latency period. This review highlights the recent knowledge on HU and provides an update on the topic of HU in consideration of a recent nationwide survey. View Full-Text
Keywords: Human T-cell lymphotropic virus; HTLV-1 uveitis; horizontal transmission; Graves’ disease; biologics Human T-cell lymphotropic virus; HTLV-1 uveitis; horizontal transmission; Graves’ disease; biologics
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MDPI and ACS Style

Kamoi, K.; Watanabe, T.; Uchimaru, K.; Okayama, A.; Kato, S.; Kawamata, T.; Kurozumi-Karube, H.; Horiguchi, N.; Zong, Y.; Yamano, Y.; Hamaguchi, I.; Nannya, Y.; Tojo, A.; Ohno-Matsui, K. Updates on HTLV-1 Uveitis. Viruses 2022, 14, 794.

AMA Style

Kamoi K, Watanabe T, Uchimaru K, Okayama A, Kato S, Kawamata T, Kurozumi-Karube H, Horiguchi N, Zong Y, Yamano Y, Hamaguchi I, Nannya Y, Tojo A, Ohno-Matsui K. Updates on HTLV-1 Uveitis. Viruses. 2022; 14(4):794.

Chicago/Turabian Style

Kamoi, Koju, Toshiki Watanabe, Kaoru Uchimaru, Akihiko Okayama, Seiko Kato, Toyotaka Kawamata, Hisako Kurozumi-Karube, Noe Horiguchi, Yuan Zong, Yoshihisa Yamano, Isao Hamaguchi, Yasuhito Nannya, Arinobu Tojo, and Kyoko Ohno-Matsui. 2022. "Updates on HTLV-1 Uveitis" Viruses 14, no. 4: 794.

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