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Volume 14
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10.3390/v14122681
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Article

Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients

by
Shaw M. Akula
1,2,*,
John F. Williams
1,
Lok R. Pokhrel
3,
Anais N. Bauer
1,
Smit Rajput
2 and
Paul P. Cook
2
1
Department of Microbiology & Immunology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
2
Department of Internal Medicine, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
3
Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA
*
Author to whom correspondence should be addressed.
Viruses 2022, 14(12), 2681; https://doi.org/10.3390/v14122681
Submission received: 8 October 2022 / Revised: 20 November 2022 / Accepted: 25 November 2022 / Published: 30 November 2022
(This article belongs to the Section SARS-CoV-2 and COVID-19)
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Abstract

Wide variability exists with host response to SARS-CoV-2 infection among individuals. Circulatory micro RNAs (miRNAs) are being recognized as promising biomarkers for complex traits, including viral pathogenesis. We hypothesized that circulatory miRNAs at 48 h post hospitalization may predict the length of stay (LOS) and prognosis of COVID-19 patients. Plasma miRNA levels were compared between three groups: (i) healthy volunteers (C); (ii) COVID-19 patients treated with remdesivir (an antiviral) plus dexamethasone (a glucocorticoid) (with or without baricitinib, a Janus kinase inhibitor) on the day of hospitalization (I); and COVID-19 patients at 48 h post treatment (T). Results showed that circulatory miR-6741-5p expression levels were significantly different between groups C and I (p < 0.0000001); I and T (p < 0.0000001); and C and T (p = 0.001). Our ANOVA model estimated that all patients with less than 12.42 Log2 CPM had a short LOS, or a good prognosis, whereas all patients with over 12.42 Log2 CPM had a long LOS, or a poor prognosis. In sum, we show that circulatory miR-6741-5p may serve as a prognostic biomarker effectively predicting mortality risk and LOS of hospitalized COVID-19 patients.
Keywords: SARS-CoV-2; miRNA; biomarker; COVID-19; LOS SARS-CoV-2; miRNA; biomarker; COVID-19; LOS

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MDPI and ACS Style

Akula, S.M.; Williams, J.F.; Pokhrel, L.R.; Bauer, A.N.; Rajput, S.; Cook, P.P. Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients. Viruses 2022, 14, 2681. https://doi.org/10.3390/v14122681

AMA Style

Akula SM, Williams JF, Pokhrel LR, Bauer AN, Rajput S, Cook PP. Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients. Viruses. 2022; 14(12):2681. https://doi.org/10.3390/v14122681

Chicago/Turabian Style

Akula, Shaw M., John F. Williams, Lok R. Pokhrel, Anais N. Bauer, Smit Rajput, and Paul P. Cook. 2022. "Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients" Viruses 14, no. 12: 2681. https://doi.org/10.3390/v14122681

APA Style

Akula, S. M., Williams, J. F., Pokhrel, L. R., Bauer, A. N., Rajput, S., & Cook, P. P. (2022). Cellular miR-6741-5p as a Prognostic Biomarker Predicting Length of Hospital Stay among COVID-19 Patients. Viruses, 14(12), 2681. https://doi.org/10.3390/v14122681

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