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Article

High SARS-CoV-2 Seroprevalence among Healthcare Workers in Bamako, Mali

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University Clinical Research Center (UCRC) Laboratory, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako PB 1805, Mali
2
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Private Bag X5, Durban 4001, South Africa
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Department of Infectious Diseases and Tropical Medicine, Point “G” University Teaching Hospital, Bamako PB 1805, Mali
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Institute for Global Health, Northwestern University, Chicago, IL 60611, USA
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Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA 17033, USA
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Department of Neurology and Center for Healthcare Delivery Science and Innovation, University of Chicago, Chicago, IL 60611, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Caijun Sun
Viruses 2022, 14(1), 102; https://doi.org/10.3390/v14010102
Received: 8 December 2021 / Revised: 25 December 2021 / Accepted: 27 December 2021 / Published: 7 January 2022
(This article belongs to the Section SARS-CoV-2 and COVID-19)
In Mali, a country in West Africa, cumulative confirmed COVID-19 cases and deaths among healthcare workers (HCWs) remain enigmatically low, despite a series of waves, circulation of SARS-CoV-2 variants, the country’s weak healthcare system, and a general lack of adherence to public health mitigation measures. The goal of the study was to determine whether exposure is important by assessing the seroprevalence of anti-SARS-CoV-2 IgG antibodies in HCWs. The study was conducted between November 2020 and June 2021. HCWs in the major hospitals where COVID-19 cases were being cared for in the capital city, Bamako, Mali, were recruited. During the study period, vaccinations were not yet available. The ELISA of the IgG against the spike protein was optimized and quantitatively measured. A total of 240 HCWs were enrolled in the study, of which seropositivity was observed in 147 cases (61.8%). A continuous increase in the seropositivity was observed, over time, during the study period, from 50% at the beginning to 70% at the end of the study. HCWs who provided direct care to COVID-19 patients and were potentially highly exposed did not have the highest seropositivity rate. Vulnerable HCWs with comorbidities such as obesity, diabetes, and asthma had even higher seropositivity rates at 77.8%, 75.0%, and 66.7%, respectively. Overall, HCWs had high SARS-CoV-2 seroprevalence, likely reflecting a “herd” immunity level, which could be protective at some degrees. These data suggest that the low number of cases and deaths among HCWs in Mali is not due to a lack of occupational exposure to the virus but rather related to other factors that need to be investigated. View Full-Text
Keywords: SARS-CoV-2; COVID-19; seroprevalence; healthcare workers; Bamako; Mali; West Africa SARS-CoV-2; COVID-19; seroprevalence; healthcare workers; Bamako; Mali; West Africa
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MDPI and ACS Style

Somboro, A.M.; Cissoko, Y.; Camara, I.; Kodio, O.; Tolofoudie, M.; Dembele, E.; Togo, A.C.G.; Ba, D.M.; Sarro, Y.d.S.; Baya, B.; Samake, S.; Diallo, I.B.; Kumar, A.; Traore, M.; Kone, B.; Kone, A.; Diarra, B.; Dabitao, D.K.; Wague, M.; Dabo, G.; Doumbia, S.; Holl, J.L.; Murphy, R.L.; Diallo, S.; Maiga, A.I.; Maiga, M.; Dao, S. High SARS-CoV-2 Seroprevalence among Healthcare Workers in Bamako, Mali. Viruses 2022, 14, 102. https://doi.org/10.3390/v14010102

AMA Style

Somboro AM, Cissoko Y, Camara I, Kodio O, Tolofoudie M, Dembele E, Togo ACG, Ba DM, Sarro YdS, Baya B, Samake S, Diallo IB, Kumar A, Traore M, Kone B, Kone A, Diarra B, Dabitao DK, Wague M, Dabo G, Doumbia S, Holl JL, Murphy RL, Diallo S, Maiga AI, Maiga M, Dao S. High SARS-CoV-2 Seroprevalence among Healthcare Workers in Bamako, Mali. Viruses. 2022; 14(1):102. https://doi.org/10.3390/v14010102

Chicago/Turabian Style

Somboro, Anou M., Yacouba Cissoko, Issiaka Camara, Ousmane Kodio, Mohamed Tolofoudie, Etienne Dembele, Antieme C. G. Togo, Djibril M. Ba, Yeya dit Sadio Sarro, Bocar Baya, Seydou Samake, Ibrahim B. Diallo, Alisha Kumar, Mohamed Traore, Bourahima Kone, Amadou Kone, Bassirou Diarra, Djeneba K. Dabitao, Mamadou Wague, Garan Dabo, Seydou Doumbia, Jane L. Holl, Robert L. Murphy, Souleymane Diallo, Almoustapha I. Maiga, Mamoudou Maiga, and Sounkalo Dao. 2022. "High SARS-CoV-2 Seroprevalence among Healthcare Workers in Bamako, Mali" Viruses 14, no. 1: 102. https://doi.org/10.3390/v14010102

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