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Communication

The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study

1
Pediatric Infectious Diseases Research Group, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
2
Department of Medicine, School of Medicine, Universitat Internacional de Catalunya, Sant Cugat, 08195 Barcelona, Spain
3
Consorcio de Investigacion Biomédica en Red Epidemiologia y Salud Pública (CIBERESP), 28029 Madrid, Spain
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Pediatric Intensive Care Unit, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
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Pediatrics Department, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
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Centro de Investigação em Saúde de Manhiça (CISM), Manhiça 1929, Mozambique
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ISGlobal, Hospital Clínic-Universitat de Barcelona, 08036 Barcelona, Spain
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Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain
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Clinical Research Unit, Fundació Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
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Centre for Genomic Regulation (CRG), Genomics Unit, 08003 Barcelona, Spain
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Epidemiological Surveillance Unit, Department of Health, Generalitat de Catalunya, 08907 Barcelona, Spain
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Department of Molecular Epidemiology, Hospital Sant Joan de Déu, Esplugues de Llobregat, 08950 Barcelona, Spain
*
Author to whom correspondence should be addressed.
These authors share co-senior authorship.
Academic Editor: Dimitrios Paraskevis
Viruses 2021, 13(8), 1598; https://doi.org/10.3390/v13081598
Received: 13 July 2021 / Revised: 4 August 2021 / Accepted: 9 August 2021 / Published: 12 August 2021
(This article belongs to the Topic Burden of COVID-19 in Different Countries)
We aimed to assess the duration of nasopharyngeal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA persistence in adults self-confined at home after acute infection; and to identify the associations of SARS-CoV-2 persistence with respiratory virus co-detection and infection transmission. A cross-sectional intra-household study was conducted in metropolitan Barcelona (Spain) during the time period of April to June 2020. Every adult who was the first family member reported as SARS-CoV-2-positive by reverse transcription polymerase chain reaction (RT-PCR) as well as their household child contacts had nasopharyngeal swabs tested by a targeted SARS-CoV-2 RT-PCR and a multiplex viral respiratory panel after a 15 day minimum time lag. Four-hundred and four households (404 adults and 708 children) were enrolled. SARS-CoV-2 RNA was detected in 137 (33.9%) adults and 84 (11.9%) children. Rhinovirus/Enterovirus (RV/EV) was commonly found (83.3%) in co-infection with SARS-CoV-2 in adults. The mean duration of SARS-CoV-2 RNA presence in adults’ nasopharynx was 52 days (range 26–83 days). The persistence of SARS-CoV-2 was significantly associated with RV/EV co-infection (adjusted odds ratio (aOR) 9.31; 95% CI 2.57–33.80) and SARS-CoV-2 detection in child contacts (aOR 2.08; 95% CI 1.24–3.51). Prolonged nasopharyngeal SARS-CoV-2 RNA persistence beyond the acute infection phase was frequent in adults quarantined at home during the first epidemic wave; which was associated with RV/EV co-infection and could enhance intra-household infection transmission. View Full-Text
Keywords: SARS-CoV-2; COVID-19; RT-PCR; rhinovirus; household SARS-CoV-2; COVID-19; RT-PCR; rhinovirus; household
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MDPI and ACS Style

Brotons, P.; Jordan, I.; Bassat, Q.; Henares, D.; Fernandez de Sevilla, M.; Ajanovic, S.; Redin, A.; Fumado, V.; Baro, B.; Claverol, J.; Varo, R.; Cuadras, D.; Hecht, J.; Barrabeig, I.; Garcia-Garcia, J.J.; Launes, C.; Muñoz-Almagro, C. The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study. Viruses 2021, 13, 1598. https://doi.org/10.3390/v13081598

AMA Style

Brotons P, Jordan I, Bassat Q, Henares D, Fernandez de Sevilla M, Ajanovic S, Redin A, Fumado V, Baro B, Claverol J, Varo R, Cuadras D, Hecht J, Barrabeig I, Garcia-Garcia JJ, Launes C, Muñoz-Almagro C. The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study. Viruses. 2021; 13(8):1598. https://doi.org/10.3390/v13081598

Chicago/Turabian Style

Brotons, Pedro, Iolanda Jordan, Quique Bassat, Desiree Henares, Mariona Fernandez de Sevilla, Sara Ajanovic, Alba Redin, Vicky Fumado, Barbara Baro, Joana Claverol, Rosauro Varo, Daniel Cuadras, Jochen Hecht, Irene Barrabeig, Juan J. Garcia-Garcia, Cristian Launes, and Carmen Muñoz-Almagro. 2021. "The Positive Rhinovirus/Enterovirus Detection and SARS-CoV-2 Persistence beyond the Acute Infection Phase: An Intra-Household Surveillance Study" Viruses 13, no. 8: 1598. https://doi.org/10.3390/v13081598

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