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Brief Report

Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster

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i3S, Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal
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Ipatimup, Instituto de Patologia e Imunologia Molecular, Universidade do Porto, 4200-135 Porto, Portugal
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ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4050-313 Porto, Portugal
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CHUSJ, Centro Hospitalar Universitário S. João, 4200-319 Porto, Portugal
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FMUP, Faculdade de Medicina da Universidade do Porto, 4200-319 Porto, Portugal
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EPIUnit, Instituto de Saúde Pública, Universidade do Porto, 4050-091 Porto, Portugal
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Author to whom correspondence should be addressed.
Academic Editors: Krisztián Bányai, István Kiss and György Lengyel
Viruses 2021, 13(6), 1116; https://doi.org/10.3390/v13061116
Received: 26 April 2021 / Revised: 4 June 2021 / Accepted: 7 June 2021 / Published: 10 June 2021
(This article belongs to the Special Issue Genomic Epidemiology of Viral Infections)
Field epidemiology and viral sequencing provide a comprehensive characterization of transmission chains and allow a better identification of superspreading events. However, very few examples have been presented to date during the COVID-19 pandemic. We studied the first COVID-19 cluster detected in Portugal (59 individuals involved amongst extended family and work environments), following the return of four related individuals from work trips to Italy. The first patient to introduce the virus would be misidentified following the traditional field inquiry alone, as shown by the viral sequencing in isolates from 23 individuals. The results also pointed out family, and not work environment, as the primary mode of transmission. View Full-Text
Keywords: COVID-19; infection cluster; viral sequencing; epidemiological survey; family versus work environment COVID-19; infection cluster; viral sequencing; epidemiological survey; family versus work environment
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MDPI and ACS Style

Pedro, N.; Fernandes, V.; Cavadas, B.; Guimarães, J.T.; Barros, H.; Tavares, M.; Pereira, L. Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster. Viruses 2021, 13, 1116. https://doi.org/10.3390/v13061116

AMA Style

Pedro N, Fernandes V, Cavadas B, Guimarães JT, Barros H, Tavares M, Pereira L. Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster. Viruses. 2021; 13(6):1116. https://doi.org/10.3390/v13061116

Chicago/Turabian Style

Pedro, Nicole, Veronica Fernandes, Bruno Cavadas, João T. Guimarães, Henrique Barros, Margarida Tavares, and Luisa Pereira. 2021. "Field and Molecular Epidemiology: How Viral Sequencing Changed Transmission Inferences in the First Portuguese SARS-CoV-2 Infection Cluster" Viruses 13, no. 6: 1116. https://doi.org/10.3390/v13061116

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