A Replicating Viral Vector Greatly Enhances Accumulation of Helical Virus-Like Particles in Plants
, Matthew J. Byrne 2, Hadrien Peyret 1, Keith Saunders 1, Roger Castells-Graells 1,3, Inmaculada Ferriol 4,5, Mattia Santoni 6, John F. C. Steele 1,7, Neil A. Ranson 2, Linda Avesani 8, Juan Jose Lopez-Moya 4,5 and George P. Lomonossoff 1,*Round 1
Reviewer 1 Report
A very interesting approach to the topic of plant virus VLPs utilizing a replicating and non-replicating potexvirus based vector and transient expression.
Author Response
We thank the reviewer for their kind comment about our interesting approach. There were no additional specific comments for us to address.
Reviewer 2 Report
Thank you for an excellent research contribution.
The main comment I have is to see if the Introduction could be improved. I found a couple of formatting issues and I thought, a more elaborate introduction would be needed, adding a paragraph on the materials and methods used and the reasoning behind why they were used would be great.
Author Response
We were pleased that the reviewer thought this was an "excellent research contribution".
The reviewer comments that they would like a further explanation of our approach in the "Introduction". We have therefore added a statement explaining this at line 68 of the revised text. We hope this is satisfactory.
