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Article

Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens

1
Public Health Regional Laboratory, Hospital Isabel Zendal, Av. Manuel Fraga Iribarne, 2, 28055 Madrid, Spain
2
Council of Public Health, Community of Madrid, Calle O’Donnell, 50, 28009 Madrid, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Manuel Ramos-Casals
Viruses 2021, 13(5), 874; https://doi.org/10.3390/v13050874
Received: 22 March 2021 / Revised: 4 May 2021 / Accepted: 5 May 2021 / Published: 10 May 2021
(This article belongs to the Special Issue COVID-19—Advances in Clinical and Epidemiological Aspects)
The virological meaning of the different patterns of serology in COVID-19 has been little examined in clinical settings. Asymptomatic subjects with IgM-spike (S) and IgG-nucleocapsid (N) determinations by chemiluminescence were studied for SARS-CoV-2 shedding in respiratory secretions by transcription-mediated amplification (TMA). In subjects showing IgM-S positive and IgG-N negative, IgG-S was determined by lateral flow assay. A total of 712 individuals were tested: 30.0% presented IgM-S(+)/IgG-N(−), 25.8% had IgM-S(+)/IgG-N(+) and 44.2% had IgM-S(−)/IgG-N(+); the proportion with TMA(+) were comparable in these three groups: 12.1, 8.7 and 10.5%, respectively. In individuals with IgM-S(+)/IgG-N(−), IgG-S(+) was detected in 66.5%. The frequency of IgM-S(+)/IgG-S(−) in the total population was 10.0%, of whom 24.1% had TMA(+); the chances for TMA(+) in subjects with an IgM-S(+) alone pattern were 2.4%. Targeting of the same SARS-CoV-2 antigen seems to be better for the characterization of IgM/IgG patterns of response. IgM-S(+) alone reactivity is rare, and a small proportion is associated with viral shedding. View Full-Text
Keywords: SARS-CoV-2; COVID-19; serology; IgM; spike; nucleocapsid SARS-CoV-2; COVID-19; serology; IgM; spike; nucleocapsid
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MDPI and ACS Style

Barreiro, P.; Candel, F.J.; Sanz, J.C.; San Román, J.; del Mar Carretero, M.; Pérez-Abeledo, M.; Ramos, B.; Viñuela-Prieto, J.M.; Canora, J.; Martínez-Peromingo, F.J.; Zapatero, A. Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens. Viruses 2021, 13, 874. https://doi.org/10.3390/v13050874

AMA Style

Barreiro P, Candel FJ, Sanz JC, San Román J, del Mar Carretero M, Pérez-Abeledo M, Ramos B, Viñuela-Prieto JM, Canora J, Martínez-Peromingo FJ, Zapatero A. Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens. Viruses. 2021; 13(5):874. https://doi.org/10.3390/v13050874

Chicago/Turabian Style

Barreiro, Pablo, Francisco J. Candel, Juan C. Sanz, Jesús San Román, María del Mar Carretero, Marta Pérez-Abeledo, Belén Ramos, José M. Viñuela-Prieto, Jesús Canora, Francisco J. Martínez-Peromingo, and Antonio Zapatero. 2021. "Virological Correlates of IgM–IgG Patterns of Response to SARS-CoV-2 Infection According to Targeted Antigens" Viruses 13, no. 5: 874. https://doi.org/10.3390/v13050874

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