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Exploring the Diversity of the Human Blood Virome

Institute for Integrative Systems Biology (I2SysBio), Universitat de València-CSIC, 46980 València, Spain
Joint Research Unit “Infection and Public Health”, FISABIO-Universitat de València I2SysBio, 46020 València, Spain
CIBER in Epidemiology and Public Health (CIBERESP), 46020 València, Spain
Centro de Transfusión de la Comunidad Valenciana, 46020 València, Spain
Department of Informatics, Universitat de València, 46020 València, Spain
Department of Genetics, Universitat de València, 46020 València, Spain
Author to whom correspondence should be addressed.
Academic Editors: Franziska Hufsky, Alba Pérez-Cataluña, Walter Randazzo, Gloria Sanchez, Fernando González-Candelas and Manja Marz
Viruses 2021, 13(11), 2322;
Received: 22 October 2021 / Revised: 15 November 2021 / Accepted: 18 November 2021 / Published: 21 November 2021
(This article belongs to the Special Issue Virus Bioinformatics 2022)
Metagenomics is greatly improving our ability to discover new viruses, as well as their possible associations with disease. However, metagenomics has also changed our understanding of viruses in general. The vast expansion of currently known viral diversity has revealed a large fraction of non-pathogenic viruses, and offers a new perspective in which viruses function as important components of many ecosystems. In this vein, studies of the human blood virome are often motivated by the search for new viral diseases, especially those associated with blood transfusions. However, these studies have revealed the common presence of apparently non-pathogenic viruses in blood, particularly human anelloviruses and, to a lower extent, human pegiviruses (HPgV). To shed light on the diversity of the human blood virome, we subjected pooled plasma samples from 587 healthy donors in Spain to a viral enrichment protocol, followed by massive parallel sequencing. This showed that anelloviruses were clearly the major component of the blood virome and showed remarkable diversity. In total, we assembled 332 complete or near-complete anellovirus genomes, 50 of which could be considered new species. HPgV was much less frequent, but we, nevertheless, recovered 17 different isolates that we subsequently used for characterizing the diversity of this virus. In-depth investigation of the human blood virome should help to elucidate the ecology of these viruses, and to unveil potentially associated diseases. View Full-Text
Keywords: orphan virus; blood virome; anellovirus; pegivirus; virus discovery; metagenomics orphan virus; blood virome; anellovirus; pegivirus; virus discovery; metagenomics
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MDPI and ACS Style

Cebriá-Mendoza, M.; Bracho, M.A.; Arbona, C.; Larrea, L.; Díaz, W.; Sanjuán, R.; Cuevas, J.M. Exploring the Diversity of the Human Blood Virome. Viruses 2021, 13, 2322.

AMA Style

Cebriá-Mendoza M, Bracho MA, Arbona C, Larrea L, Díaz W, Sanjuán R, Cuevas JM. Exploring the Diversity of the Human Blood Virome. Viruses. 2021; 13(11):2322.

Chicago/Turabian Style

Cebriá-Mendoza, María, María A. Bracho, Cristina Arbona, Luís Larrea, Wladimiro Díaz, Rafael Sanjuán, and José M. Cuevas. 2021. "Exploring the Diversity of the Human Blood Virome" Viruses 13, no. 11: 2322.

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