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Review

HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors

Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA
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Author to whom correspondence should be addressed.
Academic Editor: Stephen A. Rice
Viruses 2021, 13(10), 2015; https://doi.org/10.3390/v13102015
Received: 15 September 2021 / Revised: 2 October 2021 / Accepted: 4 October 2021 / Published: 7 October 2021
(This article belongs to the Special Issue Replication and Spread of Alphaherpesviruses)
DNA replication is an integral step in the herpes simplex virus type 1 (HSV-1) life cycle that is coordinated with the cellular DNA damage response, repair and recombination of the viral genome, and viral gene transcription. HSV-1 encodes its own DNA replication machinery, including an origin binding protein (UL9), single-stranded DNA binding protein (ICP8), DNA polymerase (UL30), processivity factor (UL42), and a helicase/primase complex (UL5/UL8/UL52). In addition, HSV-1 utilizes a combination of accessory viral and cellular factors to coordinate viral DNA replication with other viral and cellular processes. The purpose of this review is to outline the roles of viral and cellular proteins in HSV-1 DNA replication and replication-coupled processes, and to highlight how HSV-1 may modify and adapt cellular proteins to facilitate productive infection. View Full-Text
Keywords: herpes simplex virus; HSV-1; DNA replication; replication fork; recombination herpes simplex virus; HSV-1; DNA replication; replication fork; recombination
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MDPI and ACS Style

Packard, J.E.; Dembowski, J.A. HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors. Viruses 2021, 13, 2015. https://doi.org/10.3390/v13102015

AMA Style

Packard JE, Dembowski JA. HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors. Viruses. 2021; 13(10):2015. https://doi.org/10.3390/v13102015

Chicago/Turabian Style

Packard, Jessica E., and Jill A. Dembowski 2021. "HSV-1 DNA Replication—Coordinated Regulation by Viral and Cellular Factors" Viruses 13, no. 10: 2015. https://doi.org/10.3390/v13102015

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