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Case Report

Astrovirus-Associated Polioencephalomyelitis in an Alpaca

1
Institute of Veterinary Pathology, Vetsuisse-Faculty, Universitiy of Bern, 3012 Bern, Switzerland
2
Clinic for Ruminants, Vetsuisse-Faculty, University of Bern, 3012 Bern, Switzerland
3
Division of Experimental Clinical Research, Vetsuisse-Faculty, University of Bern, 3012 Bern, Switzerland
4
Institute for Veterinary Pathology, Vetsuisse-Faculty, University of Zurich, 8006 Zurich, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Valerie Cortez
Viruses 2021, 13(1), 50; https://doi.org/10.3390/v13010050
Received: 14 December 2020 / Revised: 23 December 2020 / Accepted: 25 December 2020 / Published: 30 December 2020
(This article belongs to the Special Issue New Insights into Astroviruses Research)
An 8-year-old alpaca was admitted to the emergency service of the Clinic for Ruminants in Bern due to a reduced general condition and progressive neurological signs. Despite supportive treatment, its condition deteriorated and the animal had to be euthanized. Histopathological analysis revealed a severe non-suppurative polioencephalomyelitis with neuronal necrosis, most likely of viral origin. We detected abundant neuronal labelling with antibodies directed against two different epitopes of Bovine Astrovirus CH13/NeuroS1 (BoAstV-CH13/NeuroS1), which is a common viral agent associated with non-suppurative encephalitis in Swiss cattle. These findings were further verified by detection of viral RNA by use of in-situ hybridization and real-time RT-PCR. Next generation sequencing revealed that the detected virus genome had a pairwise identity of 98.9% to the genome of BoAstV-CH13/NeuroS1. To our knowledge, this is the first report of an astrovirus-associated polioencephalomyelitis in an alpaca. These results point to the possibility of an interspecies transmission of BoAstV-CH13/NeuroS1. View Full-Text
Keywords: astrovirus; polioencephalomyelitis; alpaca; immunohistochemistry; real-time RT-PCR; next generation sequencing astrovirus; polioencephalomyelitis; alpaca; immunohistochemistry; real-time RT-PCR; next generation sequencing
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MDPI and ACS Style

Küchler, L.; Rüfli, I.; Koch, M.C.; Hierweger, M.M.; Kauer, R.V.; Boujon, C.L.; Hilbe, M.; Oevermann, A.; Zanolari, P.; Seuberlich, T.; Gurtner, C. Astrovirus-Associated Polioencephalomyelitis in an Alpaca. Viruses 2021, 13, 50. https://doi.org/10.3390/v13010050

AMA Style

Küchler L, Rüfli I, Koch MC, Hierweger MM, Kauer RV, Boujon CL, Hilbe M, Oevermann A, Zanolari P, Seuberlich T, Gurtner C. Astrovirus-Associated Polioencephalomyelitis in an Alpaca. Viruses. 2021; 13(1):50. https://doi.org/10.3390/v13010050

Chicago/Turabian Style

Küchler, Leonore; Rüfli, Isabelle; Koch, Michel C.; Hierweger, Melanie M.; Kauer, Ronja V.; Boujon, Céline L.; Hilbe, Monika; Oevermann, Anna; Zanolari, Patrik; Seuberlich, Torsten; Gurtner, Corinne. 2021. "Astrovirus-Associated Polioencephalomyelitis in an Alpaca" Viruses 13, no. 1: 50. https://doi.org/10.3390/v13010050

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