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Review

Markers Associated with COVID-19 Susceptibility, Resistance, and Severity

1
Research and Development Department, Barzan Holdings, Doha 7178, Qatar
2
Biomedical Research Center, Qatar University, Doha 2713, Qatar
*
Author to whom correspondence should be addressed.
Academic Editors: Luciana Barros de Arruda, Fabrício S. Campos and Flavio Guimaraes da Fonseca
Viruses 2021, 13(1), 45; https://doi.org/10.3390/v13010045
Received: 15 November 2020 / Revised: 29 November 2020 / Accepted: 30 November 2020 / Published: 30 December 2020
In December 2019, the latest member of the coronavirus family, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in Wuhan, China, leading to the outbreak of an unusual viral pneumonia known as coronavirus disease 2019 (COVID-19). COVID-19 was then declared as a pandemic in March 2020 by the World Health Organization (WHO). The initial mortality rate of COVID-19 declared by WHO was 2%; however, this rate has increased to 3.4% as of 3 March 2020. People of all ages can be infected with SARS-CoV-2, but those aged 60 or above and those with underlying medical conditions are more prone to develop severe symptoms that may lead to death. Patients with severe infection usually experience a hyper pro-inflammatory immune reaction (i.e., cytokine storm) causing acute respiratory distress syndrome (ARDS), which has been shown to be the leading cause of death in COVID-19 patients. However, the factors associated with COVID-19 susceptibility, resistance and severity remain poorly understood. In this review, we thoroughly explore the correlation between various host, viral and environmental markers, and SARS-CoV-2 in terms of susceptibility and severity. View Full-Text
Keywords: SARS; COVID-19; susceptibility; resistance; pathogenesis SARS; COVID-19; susceptibility; resistance; pathogenesis
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MDPI and ACS Style

Fakhroo, A.D.; Al Thani, A.A.; Yassine, H.M. Markers Associated with COVID-19 Susceptibility, Resistance, and Severity. Viruses 2021, 13, 45. https://doi.org/10.3390/v13010045

AMA Style

Fakhroo AD, Al Thani AA, Yassine HM. Markers Associated with COVID-19 Susceptibility, Resistance, and Severity. Viruses. 2021; 13(1):45. https://doi.org/10.3390/v13010045

Chicago/Turabian Style

Fakhroo, Aisha D.; Al Thani, Asmaa A.; Yassine, Hadi M. 2021. "Markers Associated with COVID-19 Susceptibility, Resistance, and Severity" Viruses 13, no. 1: 45. https://doi.org/10.3390/v13010045

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