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Review

Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies

Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore, PA 19081, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Jonathan Wilson Yewdell and Davide Angeletti
Viruses 2021, 13(1), 134; https://doi.org/10.3390/v13010134
Received: 18 December 2020 / Revised: 1 January 2021 / Accepted: 14 January 2021 / Published: 19 January 2021
(This article belongs to the Special Issue Antibodies and B Cell Memory in Viral Immunity)
Coronavirus research has gained tremendous attention because of the COVID-19 pandemic, caused by the novel severe acute respiratory syndrome coronavirus (nCoV or SARS-CoV-2). In this review, we highlight recent studies that provide atomic-resolution structural details important for the development of monoclonal antibodies (mAbs) that can be used therapeutically and prophylactically and for vaccines against SARS-CoV-2. Structural studies with SARS-CoV-2 neutralizing mAbs have revealed a diverse set of binding modes on the spike’s receptor-binding domain and N-terminal domain and highlight alternative targets on the spike. We consider this structural work together with mAb effects in vivo to suggest correlations between structure and clinical applications. We also place mAbs against severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronaviruses in the context of the SARS-CoV-2 spike to suggest features that may be desirable to design mAbs or vaccines capable of conferring broad protection. View Full-Text
Keywords: COVID-19; SARS-CoV-2; coronavirus; spike; neutralizing antibodies; immunogen COVID-19; SARS-CoV-2; coronavirus; spike; neutralizing antibodies; immunogen
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MDPI and ACS Style

Finkelstein, M.T.; Mermelstein, A.G.; Parker Miller, E.; Seth, P.C.; Stancofski, E.-S.D.; Fera, D. Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies. Viruses 2021, 13, 134. https://doi.org/10.3390/v13010134

AMA Style

Finkelstein MT, Mermelstein AG, Parker Miller E, Seth PC, Stancofski E-SD, Fera D. Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies. Viruses. 2021; 13(1):134. https://doi.org/10.3390/v13010134

Chicago/Turabian Style

Finkelstein, Maxwell T.; Mermelstein, Adam G.; Parker Miller, Emma; Seth, Paul C.; Stancofski, Erik-Stephane D.; Fera, Daniela. 2021. "Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies" Viruses 13, no. 1: 134. https://doi.org/10.3390/v13010134

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