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Virulence during Newcastle Disease Viruses Cross Species Adaptation

Base2bio, LLC, Oshkosh, WI 54905, USA
Academic Editor: Daniel Perez
Viruses 2021, 13(1), 110;
Received: 2 December 2020 / Revised: 12 January 2021 / Accepted: 13 January 2021 / Published: 15 January 2021
(This article belongs to the Special Issue Viral Cross-Species Transmission)
The hypothesis that host adaptation in virulent Newcastle disease viruses (NDV) has been accompanied by virulence modulation is reviewed here. Historical records, experimental data, and phylogenetic analyses from available GenBank sequences suggest that currently circulating NDVs emerged in the 1920–1940′s from low virulence viruses by mutation at the fusion protein cleavage site. These viruses later gave rise to multiple virulent genotypes by modulating virulence in opposite directions. Phylogenetic and pathotyping studies demonstrate that older virulent NDVs further evolved into chicken-adapted genotypes by increasing virulence (velogenic-viscerotropic pathotypes with intracerebral pathogenicity indexes [ICPIs] of 1.6 to 2), or into cormorant-adapted NDVs by moderating virulence (velogenic–neurotropic pathotypes with ICPIs of 1.4 to 1.6), or into pigeon-adapted viruses by further attenuating virulence (mesogenic pathotypes with ICPIs of 0.9 to 1.4). Pathogenesis and transmission experiments on adult chickens demonstrate that chicken-adapted velogenic-viscerotropic viruses are more capable of causing disease than older velogenic-neurotropic viruses. Currently circulating velogenic–viscerotropic viruses are also more capable of replicating and of being transmitted in naïve chickens than viruses from cormorants and pigeons. These evolutionary virulence changes are consistent with theories that predict that virulence may evolve in many directions in order to achieve maximum fitness, as determined by genetic and ecologic constraints. View Full-Text
Keywords: NDV; evolution; virulence; host adaptation NDV; evolution; virulence; host adaptation
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MDPI and ACS Style

Afonso, C.L. Virulence during Newcastle Disease Viruses Cross Species Adaptation. Viruses 2021, 13, 110.

AMA Style

Afonso CL. Virulence during Newcastle Disease Viruses Cross Species Adaptation. Viruses. 2021; 13(1):110.

Chicago/Turabian Style

Afonso, Claudio L. 2021. "Virulence during Newcastle Disease Viruses Cross Species Adaptation" Viruses 13, no. 1: 110.

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