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Article

Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States

1
Department of Veterinary Preventive Medicine, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA
2
Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14627, USA
3
Department of Medicine, University of Rochester Medical Center, Rochester, NY 14627, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daniel R Perez
Viruses 2021, 13(1), 127; https://doi.org/10.3390/v13010127
Received: 12 December 2020 / Revised: 12 January 2021 / Accepted: 12 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Viral Cross-Species Transmission)
Influenza A Viruses (IAV) in domestic swine (IAV-S) are associated with sporadic zoonotic transmission at the human–animal interface. Previous pandemic IAVs originated from animals, which emphasizes the importance of characterizing human immunity against the increasingly diverse IAV-S. We analyzed serum samples from healthy human donors (n = 153) using hemagglutination-inhibition (HAI) assay to assess existing serologic protection against a panel of contemporary IAV-S isolated from swine in the United States (n = 11). Age-specific seroprotection rates (SPR), which are the proportion of individuals with HAI ≥ 1:40, corresponded with lower or moderate pandemic risk classifications for the multiple IAV-S examined (one H1-δ1, one H1-δ2, three H3-IVA, one H3-IVB, one H3-IVF). Individuals born between 2004 and 2013 had SPRs of 0% for the five classified H3 subtype IAV-S, indicating youth may be particularly predisposed to infection with these viruses. Expansion of existing immunologic gaps over time could increase likelihood of future IAV-S spillover to humans and facilitate subsequent sustained human-to-human transmission resulting in disease outbreaks with pandemic potential. View Full-Text
Keywords: influenza A virus; orthomyxovirus; serology; immunology; swine; zoonoses influenza A virus; orthomyxovirus; serology; immunology; swine; zoonoses
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MDPI and ACS Style

Lorbach, J.N.; Fitzgerald, T.; Nolan, C.; Nolting, J.M.; Treanor, J.J.; Topham, D.J.; Bowman, A.S. Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States. Viruses 2021, 13, 127. https://doi.org/10.3390/v13010127

AMA Style

Lorbach JN, Fitzgerald T, Nolan C, Nolting JM, Treanor JJ, Topham DJ, Bowman AS. Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States. Viruses. 2021; 13(1):127. https://doi.org/10.3390/v13010127

Chicago/Turabian Style

Lorbach, Joshua N., Theresa Fitzgerald, Carolyn Nolan, Jacqueline M. Nolting, John J. Treanor, David J. Topham, and Andrew S. Bowman. 2021. "Gaps in Serologic Immunity against Contemporary Swine-Origin Influenza A Viruses among Healthy Individuals in the United States" Viruses 13, no. 1: 127. https://doi.org/10.3390/v13010127

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