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Open AccessArticle

Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug

1
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari Aldo Moro, Piazza G. Cesare 11, 70124 Bari, Italy
2
Department of Medicine, University Campus Bio-Medico of Rome, Via Alvaro del Portillo 21, 00128 Rome, Italy
*
Authors to whom correspondence should be addressed.
Academic Editor: Graciela Andrei
Viruses 2021, 13(1), 106; https://doi.org/10.3390/v13010106
Received: 19 December 2020 / Revised: 4 January 2021 / Accepted: 8 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Drug-Repositioning Opportunities for Antiviral Therapy)
In 2019 an outbreak occurred which resulted in a global pandemic. The causative agent has been identified in a virus belonging to the Coronaviridae family, similar to the agent of SARS, referred to as SARS-CoV-2. This epidemic spread rapidly globally with high morbidity and mortality. Although vaccine development is at a very advanced stage, there are currently no truly effective antiviral drugs to treat SARS-CoV-2 infection. In this study we present systematic and integrative antiviral drug repurposing effort aimed at identifying, among the drugs already authorized for clinical use, some active inhibitors of the SARS-CoV-2 main protease. The most important result of this analysis is the demonstration that ethacrynic acid, a powerful diuretic, is revealed to be an effective inhibitor of SARS-CoV-2 main protease. Even with all the necessary cautions, given the particular nature of this drug, these data can be the starting point for the development of an effective therapeutic strategy against SARS-CoV-2. View Full-Text
Keywords: coronavirus; COVID-19; SARS-CoV-2; main protease; Mpro; 3C-like protease; 3CL protease; drug repurposing; protease inhibitors coronavirus; COVID-19; SARS-CoV-2; main protease; Mpro; 3C-like protease; 3CL protease; drug repurposing; protease inhibitors
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MDPI and ACS Style

Isgrò, C.; Sardanelli, A.M.; Palese, L.L. Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug. Viruses 2021, 13, 106. https://doi.org/10.3390/v13010106

AMA Style

Isgrò C, Sardanelli AM, Palese LL. Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug. Viruses. 2021; 13(1):106. https://doi.org/10.3390/v13010106

Chicago/Turabian Style

Isgrò, Camilla; Sardanelli, Anna M.; Palese, Luigi L. 2021. "Systematic Search for SARS-CoV-2 Main Protease Inhibitors for Drug Repurposing: Ethacrynic Acid as a Potential Drug" Viruses 13, no. 1: 106. https://doi.org/10.3390/v13010106

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