Next Article in Journal
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic Outbreak
Next Article in Special Issue
A Functional K+ Channel from Tetraselmis Virus 1, a Member of the Mimiviridae
Previous Article in Journal
A Unique Relative of Rotifer Birnavirus Isolated from Australian Mosquitoes
Previous Article in Special Issue
Influence of Irradiance and Temperature on the Virus MpoV-45T Infecting the Arctic Picophytoplankter Micromonas polaris
Open AccessArticle

An Unconventional Flavivirus and Other RNA Viruses in the Sea Cucumber (Holothuroidea; Echinodermata) Virome

1
Department of Microbiology, Cornell University, Ithaca, NY 14853, USA
2
School of Biological Sciences, University of Queensland, St Lucia, Brisbane, QLD 4072, Australia
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(9), 1057; https://doi.org/10.3390/v12091057
Received: 1 September 2020 / Revised: 18 September 2020 / Accepted: 21 September 2020 / Published: 22 September 2020
(This article belongs to the Collection Unconventional Viruses)
Sea cucumbers (Holothuroidea; Echinodermata) are ecologically significant constituents of benthic marine habitats. We surveilled RNA viruses inhabiting eight species (representing four families) of holothurian collected from four geographically distinct locations by viral metagenomics, including a single specimen of Apostichopus californicus affected by a hitherto undocumented wasting disease. The RNA virome comprised genome fragments of both single-stranded positive sense and double stranded RNA viruses, including those assigned to the Picornavirales, Ghabrivirales, and Amarillovirales. We discovered an unconventional flavivirus genome fragment which was most similar to a shark virus. Ghabivirales-like genome fragments were most similar to fungal totiviruses in both genome architecture and homology and had likely infected mycobiome constituents. Picornavirales, which are commonly retrieved in host-associated viral metagenomes, were similar to invertebrate transcriptome-derived picorna-like viruses. The greatest number of viral genome fragments was recovered from the wasting A. californicus library compared to the asymptomatic A. californicus library. However, reads from the asymptomatic library recruited to nearly all recovered wasting genome fragments, suggesting that they were present but not well represented in the grossly normal specimen. These results expand the known host range of flaviviruses and suggest that fungi and their viruses may play a role in holothurian ecology. View Full-Text
Keywords: holothurian; Apostichopus; wasting; virus; flavivirus; totivirus holothurian; Apostichopus; wasting; virus; flavivirus; totivirus
Show Figures

Figure 1

MDPI and ACS Style

Hewson, I.; Johnson, M.R.; Tibbetts, I.R. An Unconventional Flavivirus and Other RNA Viruses in the Sea Cucumber (Holothuroidea; Echinodermata) Virome. Viruses 2020, 12, 1057.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop